基于专利信息的疫苗佐剂研发态势分析  

Analyzing Vaccine Adjuvant Research Trends through Patent Information

作　　者：艾青 司有辉[2] AI Qing;SI Youhui(Library,Huazhong Agricultural University,Wuhan 430070,China;National Key Laboratory of Agricultural Microbiology,Huazhong Agricultural University,Wuhan 430070,China)

机构地区：[1]华中农业大学图书馆,武汉430070 [2]华中农业大学农业微生物资源发掘与利用全国重点实验室,武汉430070

出　　处：《中国生物工程杂志》2025年第1期134-142,共9页China Biotechnology

基　　金：国家自然科学基金(32373026);中央高校基本科研业务费(2662023DKPY004)资助项目。

摘　　要：作为我国疫苗行业发展面临的“卡脖子”技术,佐剂研究已被我国《“十四五”医药工业发展规划》列为医药产业化技术攻关工程之一。依托Patsnap全球专利数据库,检索并分析了11356件疫苗佐剂相关专利,通过对专利申请趋势、技术生命周期、技术来源国和地区、创新主体、市场布局及主流佐剂研发态势等多维度进行统计分析,揭示了全球疫苗佐剂领域的研究现状与发展趋势。结果显示,全球疫苗佐剂专利主要申请人以企业为主,并且在全球范围内进行了广泛布局,而我国专利申请人在疫苗佐剂领域的专利布局相对局限,多集中在国内。在技术构成上,疫苗佐剂主要分为铝盐佐剂、乳剂佐剂、免疫增强剂和纳米佐剂四大类。在研发热点方面,铝盐佐剂仍占据主导地位,纳米佐剂作为新型佐剂发展迅速,有望成为未来研发热点。我国在免疫增强剂领域积累薄弱,但在纳米佐剂领域表现突出,有望成为我国突破疫苗佐剂技术瓶颈的关键点。As a critical technology for the development of China’s vaccine industry,adjuvant research has been listed as one of the key technology projects in the“14th Five-Year Plan”for the development of the pharmaceutical industry.This paper utilizes the global patent database Patsnap to retrieve and analyze 11356 patents related to vaccine adjuvants.By conducting a multi-dimensional statistical analysis of patent application trends,technology lifecycle,source countries and regions,innovation entities,market layout,and mainstream adjuvant research trends,the study reveals the current state and development trends of global vaccine adjuvant research.The results show that global vaccine adjuvant patents are primarily filed by enterprises and are widely distributed globally.In contrast,China’s patent filings in the vaccine adjuvant field are relatively limited,with most concentrated domestically.In terms of technological composition,vaccine adjuvants are mainly divided into four categories:aluminum salt adjuvants,emulsion adjuvants,immune enhancers,and nanoadjuvants.Regarding research hotspots,aluminum salt adjuvants continue to dominate,while nanoadjuvants,as a new type of adjuvant,are developing rapidly and are expected to be a focus of future research.Despite weak accumulation in the field of immune enhancers,China has shown outstanding performance in the field of nanoadjuvants,which is expected to become a key point for China to break through the technical bottleneck in vaccine adjuvants.

关 键 词：铝盐佐剂 乳剂佐剂 免疫增强剂 纳米佐剂 疫苗 专利分析 

分 类 号：Q819[生物学—生物工程]