皮肤真菌感染多样性和特应性皮炎  

Diversity of skin fungal infections and atopic dermatitis

作　　者：郑媛媛 李东明[1] ZHENG Yuanyuan;LI Dongming(Department of Dermatology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院皮肤科,北京100191

出　　处：《菌物学报》2025年第2期1-10,共10页Mycosystema

基　　金：国家自然科学基金(32270002,31770013)。

摘　　要：特应性皮炎(Atopic dermatitis,AD)是一种慢性炎症性皮肤病,具有湿疹的特定临床表现,伴有严重的瘙痒和搔抓,这可导致皮肤屏障破坏,继而诱发微生物感染。由于对真菌感染多样性的认识不足,对AD发生和发展过程中真菌感染的临床表现以及不同的药物治疗缺乏全面的了解,这可能会导致误诊、漏诊不正确的治疗方法。本文系统总结了AD患者发生的皮肤真菌感染的病原体的种类,包括马拉色菌属、毛癣菌属、念珠菌属等常见真菌。同时,将毛孢子菌属、假单胞菌属、黄囊壳菌属等少见的真菌属纳入分析,旨在全面了解皮肤及皮肤结构真菌感染对AD发生发展和预后的影响作用。Atopic dermatitis(AD)is a chronic inflammatory skin disorder characterized by specific clinical manifestations of eczema,accompanied by intense pruritus and scratching,which can lead to the disruption of the skin barrier and subsequently induce microbial infections.Lack of understanding diversity of fungal infections and incomplete comprehension of the clinical manifestations of fungal infections during the occurrence and progression of AD as well as improper drug treatments may lead to misdiagnosis and incorrect therapeutic approaches.This article systematically summarizes the types of pathogens causing skin fungal infections in AD patients,including common fungi such as Malassezia,Trichophyton and Candida and rare fungi such as Pseudallescheria and Xanthothecium,aiming to comprehensively understand the impact of fungal infections of the skin and its structures on the occurrence,development and prognosis of AD.

关 键 词：真菌多样性 特应性皮炎 湿疹 真菌病 

分 类 号：R758.2[医药卫生—皮肤病学与性病学] R756[医药卫生—临床医学]