母乳低聚糖检测技术研究进展  

Advances in Human Milk Oligosaccharides Detection Technology

作　　者：冯鑫 高芳 别玮 卜汉萍 韩深 汪龙飞 王金花 鲍蕾 FENG Xin;GAO Fang;BIE Wei;BU Han-Ping;HAN Shen;WANG Long-Fei;WANG Jin-Hua;BAO Lei(Science and Technology Research Center of China Customs,Beijing 100026;NestléFood Safety Institute of China,NestléR&D(China)Ltd.,Beijing 100016)

机构地区：[1]中国海关科学技术研究中心,北京100026 [2]雀巢研发(中国)有限公司雀巢食品安全研究院,北京100016

出　　处：《中国口岸科学技术》2024年第S2期35-43,共9页China Port Science and Technology

摘　　要：母乳低聚糖(Human Milk Oligosaccharides,HMOs)被认为是婴幼儿生长发育的重要营养成分之一,具有促进益生菌定植和生长、抑制致病菌定植、预防新生儿坏死性结肠炎、调节免疫力和促进脑神经发育等生理功能。部分国家和地区已批准部分HMOs可作为营养强化剂用于婴幼儿配方食品及儿童用调制乳粉。目前已有多种针对母乳或相关产品中HMOs含量的检测方法。本文详细介绍了HMOs的结构和功能,并对多项研究中涉及的检测方法进行归类比较和系统阐述,旨在深入研究HMOs检测方法特性,为促进HMOs检测方法标准化和提升各研究之间结果的可比性提供参考,进而为未来母乳成分研究和乳品质量监管提供技术支撑。Human milk oligosaccharides(HMOs)are well known as an important nutritional components of infant growth and development,eliminating pathogens,with physiological functions such as promoting the colonization and growth of probiotics,inhibiting the colonization of pathogens,preventing necrotizing enterocolitis in neonates,regulating immunity,and promoting brain and nerve development.Some regions have approved the use of certain HMOs as nutritional fortifiers in infant formula foods and modified milk powder for children.Various detection methods for HMOs content in human milk or related products have been developed.This paper provides a detailed introduction to the structure and function of HMOs,and systematically discusses and compares the detection methods involved in multiple studies.The aim is to conduct an intensive study of the characteristics of HMOs detection methods,to promote the standardization of HMOs detection methods,and to enhance the comparability of results between studies,thereby providing technical support for future human milk composition research and dairy product quality control.

关 键 词：母乳低聚糖 高效液相色谱仪 离子色谱仪 质谱仪 

分 类 号：TS252.1[轻工技术与工程—农产品加工及贮藏工程]