内热针联合富血小板血浆对膝骨性关节炎患者外周血中T细胞亚群的影响  

The effect of internal heat acupuncture combined with PRP on T cell subsets in peripheral blood of patients with knee osteoarthritis

作　　者：饶毅 吴群[2] 蔡毅[2] 梅斌 RAO Yi;WU Qun;CAI Yi;MEI Bin(China Resources&WISCO General Hospital,Hubei Wuhan 430000;THE Center Hospital Of Wuhan,Hubei Wuhan 430014)

机构地区：[1]华润武钢总医院,湖北武汉430000 [2]武汉市中心医院,湖北武汉430014

出　　处：《时珍国医国药》2025年第1期104-108,共5页Lishizhen Medicine and Materia Medica Research

基　　金：湖北省武汉市卫健委中医药科研项目(WZ22Q47);湖北省自然科学基金项目(22CFC025)。

摘　　要：目的探讨与分析内热针联合富血小板血浆(Platelet rich plasma,PRP)对膝骨性关节炎患者外周血中T细胞亚群的影响。方法选择膝骨性关节炎患者84例,根据随机掷硬币原则分为传统组42例与实验组42例。传统组给予关节腔内注射透明质酸钠治疗,实验组给予内热针联合PRP治疗,治疗观察6周。记录两组的总体疗效、视觉模拟评分(visual analogue scale,VAS)血清白细胞介素-17(Interleukin-17,IL-17)含量与外周血中T细胞亚群变化情况。结果治疗6周后实验组的总有效率为97.62%,传统组为83.33%(P<0.05);两组治疗6周后的疼痛VAS评分都低于治疗前(P<0.05),实验组与传统组相比降低更多(P<0.05);两组治疗6周后的血清IL-17含量与治疗前明显降低(P<0.05),实验组与传统组相比明显降低(P<0.05);两组治疗6周后的外周血CD4^(+)T细胞相对比例低于治疗前(P<0.05),CD8^(+)T细胞相对比例高于治疗前(P<0.05),实验组的外周血CD4^(+)T细胞、CD8^(+)T细胞相对比例与与传统组相比有统计学意义(P<0.05)。结论内热针联合PRP在膝骨性关节炎患者的应用能提高治疗效果,缓解疼痛,抑制血清IL-17的表达,调节外周血中T细胞亚群比例,从而持续改善患者的预后。Objective To explore and analysis the effect of internal heat acupuncture combined with platelet rich plasma(PRP)on T cell subsets in peripheral blood of patients with knee osteoarthritis(KOA).Methods From May 2020 to October 2023,84 cases of patients with knee osteoarthritis treated at a certain hospital were selected as the research subjects for this study.According to the principle of random coin tossing,the 84 cases of patients were divided into an experimental group of 42 cases and a traditional group of 42 cases.The traditional group were treated with intra-articular injection of sodium hyaluronate,while the experimental group were treated with internal heat acupuncture combined with PRP.The treatment were observed for 6 weeks.Recorded the overall efficacy,and changes of visual analogue scale(VAS),serum interleukin-17(IL-17)levels,T cell subsets in peripheral blood of two groups.Results After 6 weeks of treatment,the total effective rate of the experimental group were 97.62%,while that of the traditional group were 83.33%.The experimental group showed a significant improvement compared to the traditional group(P<0.05).The pain VAS scores of the experimental group and the traditional group after 6 weeks of treatment were lower than before treatment(P<0.05),and the pain VAS scores of the experimental group decreased more compared to the traditional group after 6 weeks of treatment(P<0.05).After 6 weeks of treatment,the serum IL-17 levels in the experimental group and the traditional group were significantly lower than before treatment(P<0.05).After 6 weeks of treatment,the serum IL-17 levels in the experimental group were significantly lower than those in the traditional group(P<0.05).After 6 weeks of treatment,the relative proportion of CD4^(+)T cells in peripheral blood of the experimental group and the traditional group were lower than before treatment(P<0.05),and the relative proportion of CD8^(+)T cells were higher than before treatment(P<0.05).After 6 weeks of treatment,the relative proportion of CD4^(+

关 键 词：内热针 富血小板血浆 膝骨性关节炎 T细胞亚群 白细胞介素-17 疼痛 

分 类 号：R242[医药卫生—中医临床基础]