基于信号通路的连翘酯苷A 药理作用机制研究进展  

Research progress of pharmacological mechanism of Forsythoside A based on the signaling pathways

作　　者：于洪雨 张晓旭 叶雨 万新焕 周生军 张丽[2] 牛凤菊 周长征[1] YU Hong-yu;ZHANG Xiao-xu;YE Yu;WAN Xin-huan;ZHOU Sheng-jun;ZHANG Li;NIU Feng-ju;ZHOU Chang-zheng(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Ji’nan 250355,China;Department of of Pharmacy,Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji’nan 250014,China)

机构地区：[1]山东中医药大学药学院,山东济南250300 [2]新疆医科大学第五附属医院药学部,新疆乌鲁木齐830011 [3]山东中医药大学附属医院,山东济南250014

出　　处：《时珍国医国药》2025年第1期137-143,共7页Lishizhen Medicine and Materia Medica Research

基　　金：山东省自然科学基金(ZR2021QH232);新疆维吾尔自治区自然科学基金(2022D01C582)。

摘　　要：连翘酯苷A是从中药连翘(Forsythiae Fructus)中分离出来的主要活性物质,其通过调节NF-κB、MAPK、JAK/STAT、Nrf2、NLRP3、PERK、AMPK、TLR7等多种信号转导途径,表现出显著的抗炎、抗病毒、神经保护、抗氧化、保肝、抗菌、心脑血管保护等活性。对连翘酯苷A发挥药理作用的关键通路及机制进行总结,以期为其后续临床研究及新药研发提供依据。Objective Forsythoside A,the main active substance isolated from Forsythiae Fructus,has shown significant activity in anti-inflammatory,antiviral,neuroprotection,antioxidant,liver protection,antibacterial,cardiovascular and cerebrovascular protection domains through modulating the signaling pathways like NF-κB,MAPK,JAK/STAT,Nrf2,NLRP3,PERK,AMPK and TLR7.In this paper,the key pathways and mechanisms of the pharmacologic effects of Forsythoside A were summarized in order to lay a solid foundation for the follow-up clinical studies and development of new drugs.

关 键 词：连翘酯苷A 药理作用 信号通路 作用机制 

分 类 号：R285[医药卫生—中药学]