氟骨症发病机制相关分子信号通路研究进展  

Research progress on molecular signaling pathways related to the pathogenesis of skeletal fluorosis

作　　者：王建斌 陈洪旋 张佳榕 Wang Jianbin;Chen Hongxuan;Zhang Jiarong(Institute of Medicinal Biotechnology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China;Zunyi Municipal Key Laboratory of Medicinal Biotechnology,Guizhou Provincial Research Center of Translational Medicine,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院医药生物技术研究所,遵义563000 [2]遵义医科大学附属医院遵义市医药生物技术重点实验室,贵州省转化医学工程研究中心,遵义563000

出　　处：《中华地方病学杂志》2025年第1期76-81,共6页Chinese Journal of Endemiology

基　　金：贵州省科技厅科学技术基金(黔科合基础-ZK[2021]一般485,黔科合基础-ZK[2023]一般560);遵义市科技与大数据局优秀青年人才培养专项(遵市科合HZ字[2023]198号)。

摘　　要：氟作为重要的微量元素之一,具有多种生理功能,并参与机体代谢。摄入适量氟有利于人体健康,过量氟可导致氟斑牙、氟骨症及多器官损伤。氟骨症典型症状包括骨硬化、骨软化、骨质疏松和关节软骨退行性改变等。成骨活跃和骨转换加速是形成氟骨症骨骼改变的病理基础,其受多种信号通路的综合调控。目前,氟骨症的病因已明确,但其发病机制尚无定论。近年来,研究人员对参与氟骨症发病的Notch、磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)、Wnt/β连环蛋白(β-catenin)、Hedgehog、核因子κB(NF-κB)、甲状旁腺激素(PTH)、胰岛素信号通路及其相互作用网络进行了广泛的研究。本文就近年来研究结果进行综述,以期为全面认识氟骨症发病机制提供理论依据,并为科学预防氟骨症提供研究思路。Fluorine,as one of the important trace elements,has multiple physiological functions and participates in body metabolism.Moderate intake of fluoride is beneficial for human health,while excessive fluoride can lead to dental fluorosis,skeletal fluorosis,and multi-organ damage.Typical symptoms of skeletal fluorosis include bone sclerosis,osteomalacia,osteoporosis,and degenerative changes in articular cartilage.The pathological basis for skeletal changes in fluorosis involves enhanced osteogenesis and accelerated bone turnover,which are comprehensively regulated by multiple signaling pathways.Although the etiology of skeletal fluorosis has been determined,its pathogenic mechanisms remain inconclusive.In recent years,researchers have extensively investigated the signaling pathways involved in skeletal fluorosis development,including Notch,phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR),Wnt/β-catenin,Hedgehog,nuclear factorκB(NF-κB),parathyroid hormone(PTH),and insulin signaling pathways,as well as their interactive networks.This article summarizes and reviews the recent research findings,aiming to provide a theoretical foundation for comprehensively understanding the pathogenic mechanisms of skeletal fluorosis and offer insights for scientific prevention of skeletal fluorosis.

关 键 词：氟 氟骨症 发病机制 信号通路 

分 类 号：R599[医药卫生—内科学]