抗生素治疗鼠疫的敏感性和耐药性研究进展  

Research progress on sensitivity and resistance of antibiotics to plague

作　　者：姜璇 徐大琴[2] 王鼎盛[2] 郭丽民[2] 席进孝[2] Jiang Xuan;Xu Daqin;Wang Dingsheng;Guo Limin;Xi Jinxiao(School of Public Health,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Department of Plague Prevention and Control,Gansu Center for Disease Control and Prevention,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学公共卫生学院,兰州730000 [2]甘肃省疾病预防控制中心鼠疫防制科,兰州730000

出　　处：《中华地方病学杂志》2025年第1期82-86,共5页Chinese Journal of Endemiology

基　　金：甘肃省自然科学基金(21JR11RA181);甘肃省卫生健康行业科研计划项目(GSWSKY2021-055)。

摘　　要：1943年链霉素问世,开启了鼠疫治疗的新纪元。80多年来,人类成功应用氨基糖苷类(如链霉素和庆大霉素等)、四环素类、磺胺类、氯霉素、喹诺酮类和β-内酰胺类等抗生素单一或联合治疗鼠疫患者,有效降低了鼠疫患者的死亡率;但由于细菌"风险对冲机制",鼠疫耶尔森菌(鼠疫菌)会对一些抗生素敏感性降低或产生耐药性。因此,本文对鼠疫菌耐药机制及抗生素治疗鼠疫的敏感性和耐药性进行总结分析,以期为临床医生了解传统抗生素和新型抗生素在治疗鼠疫中的应用现状,提高鼠疫患者治疗水平提供科学依据。The discovery of streptomycin in 1943 marked a new era in plague treatment.Over the subsequent eight decades,significant advances have been made through the implementation of various antibiotics,both as monotherapy and in combination regimens.These treatments have included aminoglycosides(such as streptomycin and gentamicin),tetracyclines,sulfonamides,chloramphenicol,quinolones,and beta-lactams,which have dramatically cut down the death rate from plague infections.However,due to bacterial adaptation mechanisms,Yersinia pestis can develop diminished sensitivity or resistance to certain antibiotics.This article examines the resistance mechanisms of Yersinia pestis and analyzes antimicrobial susceptibility patterns and resistance in plague treatment,aiming to provide scientific evidence for clinicians to understand the current status of traditional and new antibiotics in plague treatment and improve the treatment level of plague patients.

关 键 词：鼠疫 耐药性 抗生素敏感性 

分 类 号：R51[医药卫生—内科学]