维生素C补充和脓毒症关系:孟德尔随机化研究  

Causal relationship between vitamin C supplementation and sepsis:Mendelian randomization study

作　　者：梁金全 刘林 邵敏[1] LIANG Jinquan;LIU Lin;SHAO Min(Department of Critical Care Medicine,the First Affiliated Hospital of Anhui Medical University,Hefei 230000,Anhui,China)

机构地区：[1]安徽医科大学第一附属医院重症医学科,安徽合肥230000

出　　处：《中国现代医生》2025年第5期13-14,31,共3页China Modern Doctor

基　　金：安徽省重点研究与开发计划项目(2022e07020039)。

摘　　要：目的采用两样本孟德尔随机化(Mendelian randomization,MR)设计,评估维生素C补充与脓毒症风险关联及因果关系。方法基于全基因关联研究数据,筛选与维生素C补充相关的单核苷酸多态性作为工具变量。通过MR Egger、加权中位数法、逆方差加权法、简单模式法和加权模式法评估维生素C补充与脓毒症风险的关系。结果逆方差加权法显示维生素C补充与脓毒症风险呈负相关(P=0.030)。敏感性分析结果一致,未发现显著的异质性或多效性证据。结论维生素C补充与降低脓毒症风险间存在潜在的反向因果关系,适当补充维生素C可能为脓毒症的预防提供一种可行的干预措施。Objective To assess on-related association and causality of vitamin C supplementation and sepsis risk by using two-sample Mendelian randomization(MR)design.Methods The study was based on Genome-Wide Association Studies data to screen single nucleotide polymorphisms associated with vitamin C supplementation as instrumental variables.The association of vitamin C supplementation and risk of sepsis was assessed by MR Egger,weighted median,inverse variance weighting,simple model,and weighted model.Results Inverse variance weighting showed a significant negative association between vitamin C supplementation and the risk of sepsis(P=0.030).Sensitivity analysis was consistent with no significant evidence of significant heterogeneity or pleiotropy.Conclusion There is a potential reverse causal relationship between vitamin C supplementation and reduced sepsis risk,and appropriate vitamin C supplementation may provide a feasible intervention for sepsis prevention.

关 键 词：脓毒症 维生素C 孟德尔随机化 

分 类 号：R631.2[医药卫生—外科学]