HDL-C水平对糖尿病足患者截肢结局的预测价值  

Value of HDL-C in predicting the outcome of amputation in patients with diabetic foot

作　　者：吕相宇 任丽珏[2] 赵艳青 LYU Xiangyu;REN Lijue;ZHAO Yanqing(Graduate School of Baotou Medical College,Inner Mongolia University of Science and T,Baotou 014040,Inner Mongolia,China;Department of Endocrinology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040,Inner Mongolia,China;Department of Emergency Medicine,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040,Inner Mongolia,China)

机构地区：[1]内蒙古科技大学包头医学院研究生学院,内蒙古包头014040 [2]内蒙古科技大学包头医学院第一附属医院内分泌科,内蒙古包头014010 [3]内蒙古科技大学包头医学院第一附属医院急诊科,内蒙古包头014010

出　　处：《中国现代医生》2025年第5期35-38,共4页China Modern Doctor

基　　金：内蒙古自治区包头市卫生健康科技计划项目(wsjkkj004);内蒙古自治区高等学校科学技术研究项目(NJZY22046)。

摘　　要：目的探讨高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平对糖尿病足(diabetic foot,DF)患者截肢风险的预测价值。方法选取2020年8月至2024年6月于包头医学院第一附属医院住院治疗的110例DF患者为研究对象,根据是否截肢分为截肢组(n=23)和非截肢组(n=87),比较两组患者的相关资料,采用二元Logistic回归分析探讨DF患者截肢的影响因素,运用受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析比较HDL-C联合其他可能的危险因素对截肢结局的预测价值。结果二元Logistic回归分析显示HDL-C、住院天数、尿酸、合并下肢动脉病变为DF患者截肢的影响因素(P<0.05)。HDL-C联合合并下肢动脉病变可提高对截肢结局的预测能力。结论HDL-C水平是DF患者截肢的影响因素,对DF患者截肢有一定的预测价值。临床医生应重视HDL-C的检查,及早对DF患者进行规范化治疗,避免截肢的不良结局。Objective To explore the value of high density lipoprotein cholesterol(HDL-C)in predicting the risk of amputation in patients with diabetic foot(DF).Methods A total of 110 DF patients hospitalized in the First Affiliated Hospital of Baotou Medical College from August 2020 to June 2024 were selected as the study subjects,including 23 patients in amputation group and 87 patients in non-amputation group according to whether amputation.The related data of two groups were compared.Binary Logistic regression analysis was used to explore the influencing factors of amputation in DF patients,and receiver operating characteristic curve(ROC)was used to analyze and compare the predictive value of HDL-C combined with other possible risk factors for amputation outcome.Results A total of 110 patients were included in this study,and binary Logistic regression analysis showed that HDL-C,length of stay,uric acid,and lower extremity arterial disease were the influential factors for amputation in diabetic foot patients(P<0.05).HDL-C combined with lower extremity arterial disease can improve the ability to predict the outcome of amputation.Conclusion HDL-C level is an influential factor in the amputation of DF patients,and has a certain predictive value for the amputation of DF patients.

关 键 词：高密度脂蛋白胆固醇 糖尿病足 截肢 预测价值 

分 类 号：R587.1[医药卫生—内分泌]