中药调控自噬治疗阿尔茨海默病的研究进展  

Research progress of Chinese medicine in regulating autophagy to treat Alzheimer′s disease

作　　者：董圆霞 李宇松 马婉熔 姚宏波[3] DONG Yuanxia;LI Yusong;MA Wanrong;YAO Hongbo(School of Basic Medical Sciences,Qiqihar Medical University,Heilongjiang Province,Qiqihar 161006,China;School of Stomatological Medical College,Qiqihar Medical University,Heilongjiang Province,Qiqihar 161006,China;Department of Histology and Embryology,Qiqihar Medical University,Heilongjiang Province,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔医学院基础医学院,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院口腔医学院,黑龙江齐齐哈尔161006 [3]齐齐哈尔医学院组织与胚胎学教研室,黑龙江齐齐哈尔161006

出　　处：《中国当代医药》2025年第4期188-193,共6页China Modern Medicine

基　　金：黑龙江省自然科学基金(LH2021H122);黑龙江省大学生创新创业训练计划项目(S202311230044)。

摘　　要：阿尔茨海默病(AD)是一种常见的中枢神经系统退行性疾病,起病隐匿,发病机制复杂,对老年人身心健康造成极大威胁。目前临床治疗AD所使用药物仍以N-甲基-D-天冬氨酸拮抗剂为主,其只能延缓AD进程,无法根治该疾病。自噬是一种由溶酶体介导的通过清除异常蛋白质来维持细胞稳态的代谢过程,大量研究表明,可通过调控自噬达到减缓或治疗AD的目的。近年来,中药因低毒性、多途径、多靶点等优势在治疗AD方面前景广阔,且已证实,许多中药可通过调控自噬达到防治AD的目的。因此,本文归纳总结了近年来的相关研究成果,主要阐述了自噬在AD发生发展中的作用,从错误蛋白的沉积及级联反应层面对可调控自噬的中药作以分类归整,以期为新药的开发及应用提供参考、为临床治疗AD提供理论依据。Alzheimer's disease(AD)is a common neurodegenerative disease disordered with hidden onset and intricate pathogenesis of the central nervous system,which poses a significant threat to the physical and mental well-being of the elderly.Currently,the drugs used in clinical treatment of AD primarily give priority to N-methyl-D-aspartate antagonistsmerely.However,which can only delay the progression of AD rather than providing a fundamental cure.Autophagy is a metabolic process regulated by lysosomes that maintains cellular homeostasis through clearance of aberrant proteins,numerous studies have indicated that autophagy can slow down or treat the disease effectively.In recent years,traditional Chinese medicine has emerged as a promising avenue for AD treatment due to its low toxicity profile and ability to target multiple pathways simultaneously.At the same time,they have been confirmed that various Chinese medicines can effectively prevent and treat AD by regulating autophagy.Therefore,this article summarizes the related research achievements in recent years.It mainly elaborates the role of autophagy in the occurrence and development of AD,classifies and arranges traditional Chinese medicines that can regulate autophagy from the aspects of the deposition of misfolded proteins and cascade reactions,with the expectation of providing references for the development and application of new drugs and theoretical basis for the clinical treatment of AD.

关 键 词：阿尔茨海默病 发病机制 自噬 作用机制 中药 

分 类 号：R282.7[医药卫生—中药学]