骨膜牵张成血管治疗糖尿病足的机制研究进展  

Research progress on mechanism of periosteal distraction angiogenesis in the treatment of diabetic foot

作　　者：李佳棋 师伊 李智[3] LI Jiaqi;SHI Yi;LI Zhi(The Third Clinical College of Medicine,Shanxi Medical UniversityShanxi Bethune Hospital,Shanxi Province,Taiyuan 030000,China;Department of Emergency,Xi’an Honghui Hospital,Shaanxi Province,Xi’an 710054,China;Department of Plastic Surgery,the Third Hospital of Shanxi Medical University Shanxi Academy of Medical SciencesTongji Shanxi Hospital,Shanxi Province,Taiyuan 030000,China)

机构地区：[1]山西医科大学第三临床医学院山西白求恩医院,山西太原030000 [2]西安市红会医院急诊科,陕西西安710054 [3]山西医科大学第三医院山西医学科学院同济山西医院整形外科,山西太原030000

出　　处：《中国医药导报》2025年第4期61-65,共5页China Medical Herald

基　　金：山西省基础研究计划自然科学研究面上项目(202303021221197)。

摘　　要：胫骨横向骨搬移是在张力-应力法则作用下,通过适当的应力性牵拉刺激,骨骼受力生长时,其附着的肌肉、血管、神经可同步生长,既往多用于骨缺损、口腔颌面外科。近年来,医务工作者在胫骨横向骨搬移的基础上进行改进,将适当的力作用于骨膜,力学信号通过复杂的反应转化为化学信号,因其独特的结构,迅速动员未分化细胞,产生的细胞因子作用于全身,促进牵张区及肢体远端微血管再生和重建;在一定程度上,抑制炎症反应、促进神经修复,均可促进血管再生,打破恶性循环,多途径促进糖尿病足溃疡愈合。本文综述张力-应力法则的最新国内外临床应用及研究进展,分析血管生成的微观结构及分子机制,提出对骨膜牵张技术机制的探讨,为后期研究提供重要的理论支持。Tibial transverse transport is a process of bone growth under tension stress law,in which muscles,blood vessels,and nerves attached to bone can grow synchronously through appropriate stress tensile stimulation,it has been widely used in bone defects,oral and maxillofacial surgery in the past.In recent years,medical workers have made improvements on the basis of transverse bone transfer of tibia,applying appropriate force to periosteum,mechanical signals are converted into chemical signals through complex reactions,due to their unique structure,undifferentiated cells are rapidly mobilized,cytokines produced act on the whole body,promoting regeneration and reconstruction of microvessels ine stretching area and distal limbs;to a certain extent,inhibiting inflammatory reaction,promoting nerve repair,can promote angiogenesis,break vicious circle,promote healing of diabetic foot ulcer in multiple ways.This article reviews latest clinical applications and research progress of tension stress principle at home and abroad,analyzes microstructure and molecular mechanism of angiogenesis,proposes a discussion on mechanism of periosteal tension technology,providing important theoretical support for future research.

关 键 词：骨膜牵张 糖尿病足 牵张成血管 

分 类 号：R587.2[医药卫生—内分泌]