2009—2023年胎儿α-地中海贫血研究热点及现状的文献计量学分析  

Bibliometric analysis of hotspots and status of fetalα-thalassemia from 2009 to 2023

作　　者：李秋莹 黎新艳[2] LI Qiuying;LI Xinyan(Graduate School,Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning 530200,China;Department of Ultrasonography,Maternity and Child Health Care of Guangxi Zhuang Autonomous Region,Guangxi Zhuang Autonomous Region,Nanning 530000,China)

机构地区：[1]广西中医药大学研究生院,广西南宁530200 [2]广西壮族自治区妇幼保健院超声科,广西南宁530000

出　　处：《中国医药导报》2025年第4期116-121,共6页China Medical Herald

基　　金：国家自然科学基金资助项目(82060322);广西壮族自治区自然科学基金项目(2020GXNSFAA297066)。

摘　　要：目的通过文献计量学定量分析胎儿α-地中海贫血的热点和前沿趋势。方法采用VOSviewer和CiteSpace 6.3.1软件对Web of Science核心合集数据库、中国知网和万方数据知识服务平台2009年1月至2023年12月关于胎儿α-地中海贫血和重型α-地中海贫血的文献进行年发文量、作者、期刊、参考文献及关键词可视化分析。结果共纳入964篇中文文献和1130篇英文文献。英文发文量在2016年前呈上升趋势,2018年发文量达到顶峰,中文文献发文量于2015年最高。发文量最多的国家是美国,泰国清迈大学发文量最多。Tongsong T是英文文献发文量最高的作者,杜丽是中文文献发文量最多的作者。Hemoglobin是发文量最多的英文期刊(87篇),中国优生与遗传杂志是中文发文量最多的期刊。共被引文献聚类排名前3位的是基因编辑、多态性、羟基脲。关键词分析产前诊断、基因型、基因诊断和治疗策略为该领域的高频词汇,基因治疗可能是未来的研究焦点。结论该领域的研究主要集中在产前诊断和治疗策略方面。无创产前诊断和治疗方法的进展将改变目前胎儿重型α-地中海贫血的管理方式。Objective To quantitatively analyze the hotspots and frontier trends of fetalα-thalassemia by bibliometrics.Methods VOSviewer and CiteSpace 6.3.1 software were used to analyze the annual publication volume,authors,journals,references and keywords of the literature on fetalα-thalassemia and severeα-thalassemia from Janaury 2009 to December 2023 in the core collection of Web of Science database,China National Knowledge Infrastructure and Wanfang database knowledge service platform.Results A total of 964 Chinese articles and 1130 English articles were included.The publication of English articles exhibited an upward trend prior to 2016,reaching its peak in 2018,while the publication of Chinese articles was the highest in 2015.The country with the highest number of publications was the United States,and Chiang Mai University in Thailand had the most.Tongsong T emerged as the most prolific author in the English literature,whereas Du Li was identified as the leading authors in the Chinese literature.The journal Hemoglobin published the highest number of English articles(87 articles),while the Chinese Journal of Eugenics and Genetics was the most prolific in the Chinese language.The top three clusters of co-cited literature were identified as gene editing,polymorphism,and hydroxyurea.Keyword analysis revealed that prenatal diagnosis,genotype,gene diagnosis,and treatment strategies were high-frequency terms in this field,indicated that gene therapy may become a focal point of future research endeavors.Conclusion Recent research on this topic has primarily focused on prenatal diagnosis and treatment strategies.A particular area of interest is the ongoing research on gene therapy.The advances in non-invasive diagnosis and therapeutic methods will change the current management approaches for severe fetalα-thalassemia in the future.

关 键 词：胎儿α-地中海贫血 可视化分析 文献计量学 VOSviewer CITESPACE 

分 类 号：R714.55[医药卫生—妇产科学]