柴芍六君子汤加减治疗肝郁脾虚型功能性便秘的临床疗效研究  

Clinical study of modified Chaishao Liujunzi Decoction in treating functional constipation of liver depression and spleen deficiency type

作　　者：周联菲 刘继友 张超强 单丽萍 ZHOU Lian-fei;LIU Ji-you;ZHANG Chao-qiang(Tongshan District Hospital of Traditional Chinese Medicine Xuzhou 221000,China)

机构地区：[1]徐州市铜山区中医院,221000

出　　处：《中国现代药物应用》2025年第4期9-13,共5页Chinese Journal of Modern Drug Application

基　　金：徐州市中医药科技发展计划项目(项目编号:XZYB2021047)。

摘　　要：目的研究柴芍六君子汤加减治疗肝郁脾虚型功能性便秘的临床疗效。方法60例肝郁脾虚型功能性便秘患者,按随机数字表法分为对照组和观察组,各30例。对照组患者予以乳果糖治疗,观察组患者予以柴芍六君子汤加减治疗。比较两组患者疗效,中医证候积分,便秘患者生活质量评估量表(PAC-QOL)、便秘患者症状自评量表(PAC-SYM)评分,肠电图,复发率。结果观察组总有效率(93.33%)高于对照组(70.00%)(P<0.05)。治疗前,两组患者大便干结、排便时间延长、排便次数减少、排便费力、腹痛胀坠、纳差、嗳气呃逆、肢困神疲、烦躁或抑郁、口干口苦积分比较,差异无统计学意义(P>0.05);治疗后,两组患者大便干结、排便时间延长、排便次数减少、排便费力、腹痛胀坠、纳差、嗳气呃逆、肢困神疲、烦躁或抑郁、口干口苦积分均低于治疗前,且观察组大便干结积分(1.67±0.76)分、排便时间延长积分(1.73±0.87)分、排便次数减少积分(1.67±0.76)分、排便费力积分(1.87±0.73)分、腹痛胀坠积分(0.83±0.38)分、纳差积分(0.93±0.25)分、嗳气呃逆积分(0.77±0.43)分、肢困神疲积分(0.90±0.35)分、烦躁或抑郁积分(0.90±0.31)分、口干口苦积分(0.87±0.35)分低于对照组的(2.33±0.92)、(2.27±1.01)、(2.13±0.90)、(2.40±0.81)、(1.03±0.32)、(1.33±0.48)、(1.23±0.43)、(1.17±0.46)、(1.17±0.46)、(1.07±0.37)分(P<0.05)。治疗后,两组患者PAC-QOL、PAC-SYM评分均较治疗前明显下降,且观察组PAC-QOL评分(33.53±5.11)分、PAC-SYM评分(8.70±2.35)分低于对照组的(44.80±5.59)、(11.40±2.51)分(P<0.05)。治疗后,两组患者升结肠和降结肠的电活动频率及振幅均明显较治疗前升高,且观察组高于对照组(P<0.05)。观察组随访3个月的复发率10.00%低于对照组的36.67%,差异有统计学意义(χ2=5.963,P=0.015<0.05)。结论与乳果糖相比,采用柴芍六君子汤加减治疗肝郁脾虚型功能性便Objective To study the study the clinical efficacy of modified Chaishao Liujunzi Decoction in treating functional constipation of liver depression and spleen deficiency type.Methods 60 patients with functional constipation of liver depression and spleen deficiency type were divided into control group and observation group according to random numerical table,with 30 cases in each group.The control group was treated with lactulose,and the observation group was treated with modified Chaishao Liujunzi Decoction.Both groups were compared in terms of efficacy,traditional Chinese medicine syndrome score,Patient Assessment of Constipation Quality of Life(PAC-QOL),Patient Assessment of Constipation Symptom(PAC-SYM)score,electroenterogram and recurrence rate.Results The total effective rate of the observation group(93.33%)was higher than that of the control group(70.00%)(P<0.05).Before treatment,there was no statistically significant difference in scores of dry stool,prolonged defecation time,reduced defecation frequency,difficult defecation,abdominal pain and distension,poor appetite,belching and retching,limb sleepiness and fatigue,irritability or depression,and dry mouth and bitter mouth between the two groups(P>0.05).After treatment,the scores of dry stool,prolonged defecation time,reduced defecation frequency,difficult defecation,abdominal pain and distension,poor appetite,belching and retching,limb sleepiness and fatigue,irritability or depression,and dry mouth and bitter mouth in both groups were lower than those before treatment;in the observation group,the score of dry stool was(1.67±0.76)points,the score of prolonged defecation time was(1.73±0.87)points,the score of reduced defecation frequency was(1.67±0.76)points,the score of difficult defecation was(1.87±0.73)points,the score of abdominal pain and distension was(0.83±0.38)points,the score of poor appetite was(0.93±0.25)points,the score of belching and retching was(0.77±0.43)points,the score of limb sleepiness and fatigue was(0.90±0.35)points,the score

关 键 词：柴芍六君子汤加减 肝郁脾虚型 功能性便秘 

分 类 号：R256.35[医药卫生—中医内科学]