格列吡嗪和二甲双胍治疗2型糖尿病的效果及对胰岛素敏感指数的影响  

Effect of glipizide and metformin in the treatment of type 2 diabetes mellitus and their influence on insulin sensitivity index

作　　者：寻玉君[1] 单鹏[2] XUN Yu-jun;SHAN Peng(Tengzhou Traditional Chinese Medicine Hospital,Zaozhuang 277500,China)

机构地区：[1]滕州市中医医院,277500 [2]滕州市中心人民医院,277500

出　　处：《中国现代药物应用》2025年第4期130-133,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析格列吡嗪和二甲双胍治疗2型糖尿病的效果及对胰岛素敏感指数的影响。方法80例2型糖尿病患者,采取乱数表法将其分为格列吡嗪组与二甲双胍组,各40例。格列吡嗪组给予格列吡嗪片口服治疗,二甲双胍组给予盐酸二甲双胍缓释片口服治疗。对比两组不良反应发生情况,治疗前后血糖指标、临床相关指标[血压、血脂、胰岛素敏感指数(ISI)]。结果治疗4周后,二甲双胍组空腹血糖(8.03±1.01)mmol/L、餐后2 h血糖(12.25±2.17)mmol/L、糖化血红蛋白(6.01±1.19)%均低于格列吡嗪组的(8.81±1.19)mmol/L、(13.69±3.91)mmol/L、(7.25±1.14)%(P<0.05)。二甲双胍组不良反应发生率10.0%显著低于格列吡嗪组的40.0%(P<0.05)。治疗后,二甲双胍组收缩压(122.18±6.47)mm Hg(1 mm Hg=0.133 kPa)、总胆固醇(4.41±1.39)mmol/L、甘油三酯(1.79±0.98)mmol/L均低于格列吡嗪组的(129.41±4.09)mm Hg、(5.63±2.13)mmol/L、(2.49±1.67)mmol/L,高密度脂蛋白胆固醇(1.41±0.51)mmol/L、lnISI(-4.43±0.44)均高于格列吡嗪组的(0.99±0.39)mmol/L、(-4.73±0.39)(P<0.05)。结论采取二甲双胍治疗2型糖尿病患者效果良好,能够合理控制血糖指标,改善ISI,具有较高的安全性,可推广应用。Objective To analyze the effect of glipizide and metformin in the treatment of type 2 diabetes mellitus and their influence on insulin sensitivity index.Methods 80 patients with type 2 diabetes mellitus were divided into glipizide group and metformin group by random number table method,each with 40 cases.The glipizide group was given glipizide tablets,and the metformin group was given metformin hydrochloride sustained-release tablets.The occurrence of adverse reactions,blood glucose index,related clinical indicators[blood pressure,blood lipid,insulin sensitivity index(ISI)]before and after treatment were compared between the two groups.Results After 4 weeks of treatment,the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin were(8.03±1.01)mmol/L,(12.25±2.17)mmol/L and(6.01±1.19)%in the metformin group,which were lower than(8.81±1.19)mmol/L,(13.69±3.91)mmol/L and(7.25±1.14)%in the glipizide group(P<0.05).The incidence of adverse reactions in the metformin group(10.0%)was significantly lower than that in the glipizide group(40.0%)(P<0.05).After treatment,the systolic blood pressure,total cholesterol and triglyceride were(122.18±6.47)mm Hg(1 mm Hg=0.133 kPa),(4.41±1.39)mmol/L and(1.79±0.98)mmol/L in the metformin group,which were lower than(129.41±4.09)mm Hg,(5.63±2.13)mmol/L and(2.49±1.67)mmol/L in the glipizide group;the high density lipoprotein cholesterol and lnISI were(1.41±0.51)mmol/L and(-4.43±0.44)in the metformin group,which were higher than(0.99±0.39)mmol/L and(-4.73±0.39)in the glipizide group(P<0.05).Conclusion Metformin has a good effect in the treatment of type 2 diabetes mellitus patients,and can reasonably control blood glucose index and improve ISI.It has a high safety and can be popularized.

关 键 词：格列吡嗪 二甲双胍 2型糖尿病 胰岛素敏感指数 

分 类 号：R58[医药卫生—内分泌]