草乌甲素联合热奄包治疗KOA真实世界研究  

The real world study of bulleyaconitine A combined with hot package in the treatment of KOA

作　　者：杨玉鑫 马笃军[2] 毕玉杰 周宇昊 文胤翔 钟秋辉 YANG Yuxin;MA Dujun;BI Yujie;ZHOU Yuhao;WEN Yinxiang;ZHONG Qiuhui(The Fourth Clinical Medical College,Guangzhou University of Chinese Medicine,Shenzhen 518033,Guangdong,China;Department of Orthopedics,Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033,Guangdong,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院骨伤科,广东深圳5180331

出　　处：《中国现代医生》2025年第6期65-68,共4页China Modern Doctor

基　　金：深圳市卫生健康菁英人才项目(2021XKG004)。

摘　　要：目的 分析真实世界草乌甲素片联合椒盐七子散热奄包治疗膝骨关节炎(knee osteoarthritis,KOA)的临床疗效。方法 选取2023年12月至2024年8月深圳市中医院骨伤科门诊患者110例,随机分为对照组53例和治疗组57例。对照组患者外用氟比洛芬凝胶贴膏,治疗组患者口服草乌甲素片,外用椒盐七子散热奄包治疗,疗程均为4周;治疗结束后2周对所有患者进行随访。比较两组患者的西安大略和麦克马斯特大学骨关节炎指数(Western Ontario and McMaster University osteoarthritis index,WOMAC)评分、Lequesne评分、健康调查简表(12-item short form health survey,SF-12)评分及临床疗效,并记录不良事件。结果 治疗组的总有效率为87.7%,显著高于对照组的71.7%(P<0.05);治疗后两组患者的WOMAC评分、Lequesne评分、SF-12评分均优于治疗前(P<0.05);且治疗组患者的WOMAC评分、Lequesne评分、SF-12评分改善更明显(P<0.05)。结论 对寒湿痹阻证KOA患者使用草乌甲素片联合椒盐七子散热奄包治疗,可减轻膝关节疼痛,改善膝关节活动功能,提高患者的生活质量。Objective To analyze the clinical efficacy of real-world bulleyaconitine A tablets combined with salt and pepper seven-seed hot package in the treatment of knee osteoarthritis(KOA).Methods 110 outpatient patients from the Department of Orthopedics,Shenzhen Traditional Chinese Medicine Hospital from December 2023 to August 2024 were selected,they were randomly divided into control group of 53 cases and treatment group of 57 cases.The patients in control group were treated with flurbiprofen gel paste,the patients in treatment group received oral administration of bulleyaconitine A tablets and external application of Jiaoyan Qizi hot package,the treatment course were all 4 weeks.All patients were followed up for 2 weeks after the end of treatment.Western Ontario and McMaster University osteoarthritis index(WOMAC)score,Lequesne score,12-item short form health survey(SF-12)score and clinical efficacy were compared between two groups,and adverse events were recorded.Results The total effective rate of treatment group was 87.7%,which was significantly higher than 71.7%of control group(P<0.05);After treatment,WOMAC score,Lequesne score and SF-12 score in two groups were better than before treatment(P<0.05).The improvement of WOMAC score,Lequesne score and SF-12 score in treatment group were more obvious(P<0.05).Conclusion For KOA patients with cold and damp obstruction syndrome,the use of bulleyaconitine A tablets combined with Jiaoyan Qizi hot package can alleviate knee joint pain,improve knee joint mobility,and enhance patients’quality of life.

关 键 词：膝骨关节炎 真实世界研究 草乌甲素 热奄包 

分 类 号：R274.9[医药卫生—中西医结合]