高胆固醇血症患者脂质过氧化及抗氧化能力的变化  

Changes of lipid peroxidation and antioxidant capacity in patients with hypercholesterolemia

作　　者：那春鑫 刘琼 于卓可 季梦祺 闫月乔 赵颖 姜凤艳 杨忠艳 NA Chunxin;LIU Qiong;YU Zhuoke;JI Mengqi;YAN Yueqiao;ZHAO Ying;JIANG Fengyan;YANG Zhongyan(Department of Clinical Laboratory,the People’s Hospital of Qitaihe,Qitaihe 154600,Heilongjiang,China;Department of Clinical Laboratory,Zhenjiang 359 Hospital,Zhenjiang 212000,Jiangsu,China;Department of Clinical Laboratory,Daqing Longfeng District Disease Prevention and Control Center,Daqing 163000,Heilongjiang,China)

机构地区：[1]七台河市人民医院检验科,黑龙江七台河154600 [2]镇江三五九医院检验科,江苏镇江212000 [3]大庆市龙凤区疾病预防控制中心检验科,黑龙江大庆163000

出　　处：《中国现代医生》2025年第7期11-13,31,共4页China Modern Doctor

基　　金：黑龙江省卫生健康委科研项目(20231111000228)。

摘　　要：目的研究高胆固醇血症患者的脂质过氧化及抗氧化能力变化。方法选取2024年1月至5月于七台河市人民医院就诊的100例胆固醇升高患者纳入高胆固醇血症组,另选取同期本院80例体检血脂正常者纳入对照组。测定所有研究对象的丙二醛(malondialdehyde,MDA)、谷胱甘肽(glutathione,GSH)、谷胱甘肽还原酶(glutathione reductase,GR)及总抗氧化能力(total antioxidant capacity,TAC)。结果高胆固醇血症组患者的总胆固醇、低密度脂蛋白胆固醇、MDA水平显著高于对照组,GSH、GR、TAC水平均显著低于对照组(P<0.05)。结论高胆固醇血症患者存在严重的脂质过氧化,可能引起血管内皮细胞损伤。Objective To study the changes of lipid peroxidation and antioxidant capacity in patients with hypercholesterolemia.Methods A total of 100 patients with elevated cholesterol treated in the People’s Hospital of Qitaihe from January to May 2024 were included in hypercholesterolemia group,and another 80 people with normal blood lipid in the hospital during the same period were included in control group.Malondialdehyde(MDA),glutathione(GSH),glutathione reductase(GR)and total antioxidant capacity(TAC)were determined in all subjects.Results The levels of total cholesterol,low density lipoprotein-cholesterol and MDA in hypercholesterolemia group were significantly higher than those in control group,while the levels of GSH,GR and TAC were significantly lower than those in control group(P<0.05).Conclusion Patients with hypercholesterolemia have severe lipid peroxidation,which may cause vascular endothelial cell damage.

关 键 词：高胆固醇血症 脂质过氧化 抗氧化 

分 类 号：R541.8[医药卫生—心血管疾病]