多模态超声联合性激素检测对不孕患者子宫内膜容受性的评估  

Evaluation of endometrial receptivity in infertile patients using multimodal ultrasound combined with sex hormone detection

作　　者：丁延华 姚继芹 林珍云 朱晓玲 朱晓青 DING Yanhua;YAO Jiqin;LIN Zhenyun;ZHU Xiaoling;ZHU Xiaoqing(Department of Ultrasound,Hangzhou Women’s Hospital,Hangzhou 310008,Zhejiang,China;Department of Reproductive Medicine,Hangzhou Women’s Hospital,Hangzhou 310008,Zhejiang,China)

机构地区：[1]杭州市妇产科医院超声科,浙江杭州310008 [2]杭州市妇产科医院生殖医学科,浙江杭州310008

出　　处：《中国现代医生》2025年第7期24-27,共4页China Modern Doctor

基　　金：浙江省杭州市科学技术局项目(2022WJC168)。

摘　　要：目的探讨应用多模态超声联合性激素检测评估不孕患者子宫内膜容受性的价值。方法选取2020年1月至2023年2月于杭州市妇产科医院接受体外受精-胚胎移植治疗的不孕患者95例为研究对象,根据首次胚胎移植妊娠情况将其分为妊娠组(55例)和未妊娠组(40例)。比较两组患者的性激素水平及多模态超声检查评分,并绘制受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)评估各项指标单独及联合预测不孕患者妊娠情况的价值。结果妊娠组患者的子宫内膜厚度评分、子宫内膜容积评分、血管化血流评分及多模态超声检查评分均显著高于未妊娠组(P<0.05);妊娠组患者的黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E_(2))、孕酮(progesterone,P)均显著高于未妊娠组(P<0.05);ROC曲线结果显示,LH、E_(2)及多模态超声检查评分预测不孕患者妊娠情况的曲线下面积(area under the curve,AUC)均>0.7,具有一定的预测价值,三者联合P的预测价值最高,AUC为0.889。结论多模态超声联合性激素检测对不孕患者子宫内膜容受性可进行有效评估,对不孕患者妊娠情况的预测有一定参考价值。Objective To explore the value of multimodal ultrasound combined with sex hormone detection in evaluating endometrial receptivity in infertile patients.Methods Ninety-five infertile patients who received in vitro fertilization and embryo transfer treatment in Hangzhou Women’s Hospital from January 2020 to February 2023 were selected as study objects,and they were divided into pregnant group(55 cases)and non-pregnant group(40 cases)according to the pregnancy status of the first embryo transfer.Sex hormone levels and multimodal ultrasound scores were compared between two groups,and receiver operating characteristic(ROC)curve was drawn to evaluate the value of each indicator in predicting pregnancy of infertile patients individually and in combination.Results The endometrial thickness score,endometrial volume score,vascular blood flow score and multimodal ultrasound score of pregnant group were significantly higher than those of non-pregnant group(P<0.05).The levels of luteinizing hormone(LH),estradiol(E_(2))and progesterone(P)in pregnant group were significantly higher than those in non-pregnant group(P<0.05).ROC curve results showed that the area under the curve(AUC)of LH,E_(2)and multimodal ultrasound scores in predicting pregnancy in infertile patients were all>0.7,which had certain predictive value,and the three indicators combined with P had the highest predictive value,with an AUC of 0.889.Conclusion The combination of multimodal ultrasound and sex hormone detection can effectively evaluate the endometrial receptivity of infertile patients,and has certain reference value for predicting the pregnancy status of infertile patients.

关 键 词：子宫内膜容受性 多模态超声 性激素 黄体生成素 雌二醇 孕酮 

分 类 号：R445.1[医药卫生—影像医学与核医学] R446.1[医药卫生—诊断学]