巨幼细胞贫血患者白细胞水平与血细胞指标的相关性分析  

Correlation analysis of white blood cell level and blood cell indexes in megaloblastic anemia patients

作　　者：孙梦佳 孟杭锋 SUN Mengjia;MENG Hangfeng(Clinical Laboratory,Adicon Medical Laboratory Center,Hangzhou 310030,Zhejiang,China)

机构地区：[1]杭州艾迪康医学检验中心临床实验室,浙江杭州310030

出　　处：《中国现代医生》2025年第7期43-45,80,共4页China Modern Doctor

摘　　要：目的分析巨幼细胞贫血(megaloblastic anemia,MA)患者白细胞(white blood cell,WBC)与血细胞指标的相关性。方法选取2023年6月至2024年6月在杭州艾迪康医学检验中心经骨髓细胞形态学检查诊断为MA患者79例纳入MA组,另选取40名同期接受健康体检者纳入健康组。检测并比较两组研究对象的WBC、红细胞(red blood cell,RBC)、血小板(platelet,PLT)、血红蛋白(hemoglobin,Hb)、平均红细胞血红蛋白含量(mean corpuscular hemoglobin,MCH)和平均红细胞体积(mean corpuscular volume,MCV),使用Spearman相关性分析各参数的相关性,采用受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析WBC对MA的诊断价值。结果MA组患者的WBC、PLT、Hb、RBC水平均显著低于健康组(P<0.05),MCH和MCV水平均显著高于健康组(P<0.05);WBC与PLT、Hb、RBC均呈正相关(P<0.05),与MCH和MCV均呈负相关(P<0.05);ROC曲线分析显示,WBC诊断MA的曲线下面积为0.926(95%CI:0.876~0.975);重度及以上组患者的PLT、Hb、RBC水平均显著低于轻中度组(P<0.05);MA患者的贫血程度与PLT、Hb、RBC水平均呈负相关(P<0.05),贫血越严重,PLT、Hb、RBC水平越低。结论WBC和RBC变化与MA的发生有关,且WBC可作为诊断MA的参考指标。Objective To analyze the correlation between white blood cell(WBC)and blood cell indexes in megaloblastic anemia(MA)patients.Methods A total of 79 patients diagnosed as MA by bone marrow cell morphology at Adicon Medical Laboratory Center from June 2023 to June 2024 were included in MA group,and another 40 healthy physical examination subjects during the same period were included in health group.The levels of WBC,red blood cell(RBC),platelet(PLT),hemoglobin(Hb)and mean corpuscular hemoglobin(MCH),mean corpuscular volume(MCV)were measured and compared between two groups.Spearman correlation was used to analyze the correlation of each parameter.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of WBC in MA.Results The levels of WBC,PLT,Hb and RBC in MA group were significantly lower than those in healthy group(P<0.05),MCH and MCV levels were significantly higher than those of healthy group(P<0.05).WBC was positively correlated with PLT,Hb and RBC(P<0.05),and were negatively correlated with MCH and MCV(P<0.05).ROC curve analysis showed that the area under the curve of WBC diagnosis MA was 0.926(95%CI:0.876-0.975).The levels of PLT,Hb and RBC in severe and above group were significantly lower than those in mild to moderate group(P<0.05).The degree of anemia in MA patients was negatively correlated with the levels of PLT,Hb and RBC(P<0.05),and the more severe the anemia,the lower the levels of PLT,Hb and RBC.Conclusion The changes of WBC and RBC are related to the occurrence of MA,and WBC can be used as a reference index for the diagnosis of MA.

关 键 词：白细胞 红细胞 巨幼细胞贫血 诊断价值 

分 类 号：R556[医药卫生—血液循环系统疾病]