nCD64指数、CRP、IL-6与PCT在病毒性和细菌性上呼吸道感染中的诊断价值  

Diagnostic value of nCD64 index,CRP,IL-6 and PCT in viral and bacterial upper respiratory tract infections

作　　者：吴军良 朱明利[1] 黄谦[3] 雷松玲 程江豪 WU Junliang;ZHU Mingli;HUANG Qian;LEI Songling;CHENG Jianghao(Open Laboratory,Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310023,Zhejiang,China;Department of Laboratory Medicine,Affiliated Jinhua Hospital,School of Medicine Zhejiang University,Jinhua 321000,Zhejiang,China;Department of Infectious Disease,Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310023,Zhejiang,China)

机构地区：[1]浙江中医药大学附属杭州市西溪医院开放实验室,浙江杭州310023 [2]浙江大学医学院附属金华医院检验科,浙江金华321000 [3]浙江中医药大学附属杭州市西溪医院感染科,浙江杭州310023

出　　处：《中国现代医生》2025年第7期46-49,共4页China Modern Doctor

摘　　要：目的探讨中性粒细胞CD64(neutrophils CD64,nCD64)指数、C反应蛋白(C reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)和降钙素原(procalcitonin,PCT)水平对病毒性和细菌性上呼吸道感染的诊断价值。方法选取2023年1月至2024年1月浙江中医药大学附属杭州市西溪医院诊治的上呼吸道感染患者为研究对象,根据病原学检查结果将其分为细菌感染组(46例)和病毒感染组(58例)。比较两组患者用药前nCD64指数、CRP、IL-6和PCT水平。采用受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)评估感染标志物对细菌性、病毒性上呼吸道感染的鉴别诊断价值。结果细菌感染组患者的CRP、nCD64指数、IL-6、PCT水平均显著高于病毒感染组(P<0.01)。ROC曲线结果显示,nCD64指数、CRP、PCT、IL-6鉴别两种感染类型的曲线下面积(area under the curve,AUC)分别为0.818、0.776、0.692、0.654,四者联合的AUC为0.870(95%CI:0.796~0.943)。结论nCD64指数、CRP、IL-6和PCT均与上呼吸道感染患者病原类型关系密切,各指标联合检测可提高对上呼吸道感染类型的诊断效能。Objective To investigate the diagnostic value of neutrophils CD64(nCD64)index,C reactive protein(CRP),interleukin-6(IL-6)and procalcitonin(PCT)in viral and bacterial upper respiratory tract infections.Methods Patients with upper respiratory tract infection treated in Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University from January 2023 to January 2024 were selected as study objects.According to the results of etiological examination,they were divided into bacterial infection group(46 cases)and viral infection group(58 cases).The levels of nCD64 index,CRP,IL-6 and PCT before medication were compared between two groups.Receiver operating characteristic(ROC)curve was used to evaluate the value of infection markers in the differential diagnosis of bacterial and viral upper respiratory tract infections.Results The levels of CRP,nCD64 index,IL-6 and PCT in bacterial infection group were significantly higher than those in viral infection group(P<0.01).ROC curve results showed that the area under the curve(AUC)of nCD64 index,CRP,PCT and IL-6 to distinguish the two types of infection were 0.818,0.776,0.692 and 0.654,respectively,and the combined AUC of four indexes was 0.870.Conclusion nCD64 index,CRP,IL-6 and PCT are closely related to the pathogen types of patients with upper respiratory tract infection,and the combined detection of all indicators can improve the diagnostic efficiency of upper respiratory tract infection types.

关 键 词：中性粒细胞CD64指数 C反应蛋白 白细胞介素-6 降钙素原 细菌性感染 病毒性感染 

分 类 号：R446[医药卫生—诊断学]