血清TIMP-1、Gal-3联合IL-17对老年急性心肌梗死患者PCI后支架内再狭窄的预测价值  

Prediction Value of in Stent Restenosis in Elderly Patients with Acute Myocardial Infarction After PCI Using Serum TIMP-1,Gal-3,and IL-17

作　　者：吕国伟 张志峰 赵帅 LÜ Guowei;ZHANG Zhifeng;ZHAO Shuai(Department of CardiologyⅡ,Shangqiu Hospital of Traditional Chinese Medicine,Shangqiu 476000,China)

机构地区：[1]商丘市中医院心内二科,河南商丘476000

出　　处：《河南医学研究》2025年第4期646-650,共5页Henan Medical Research

摘　　要：目的分析血清基质金属蛋白酶组织抑制因子-1(TIMP-1)、半乳糖凝集素-3(Gal-3)联合白细胞介素-17(IL-17)对老年急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)后支架内再狭窄的预测价值,为支架内再狭窄的预防提供依据。方法前瞻性研究纳入商丘市中医院2018年8月至2021年8月治疗的105例AMI患者作为研究对象;入院后给予患者急诊PCI;术后3 d,测定患者血清TIMP-1、Gal-3、IL-17水平。出院后对患者进行跟踪随访,随访时间截至2022年8月,根据冠状动脉血管造影检查结果评估患者支架内再狭窄发生情况,分析血清TIMP-1、Gal-3联合IL-17对老年AMI患者PCI后支架内再狭窄的预测价值。结果随访时间截至2022年8月,105例老年AMI患者支架内再狭窄发生率为13.33%;狭窄组入院时收缩压、舒张压、空腹血糖、血清TIMP-1、Gal-3、IL-17水平高于非狭窄组(P<0.05);经Point-biserial相关性分析显示,血清TIMP-1、Gal-3、IL-17与老年AMI患者介入后支架内再狭窄呈正相关(r>0,P<0.05);绘制受试者工作特征(ROC)曲线,结果显示血清TIMP-1、Gal-3、IL-17单独及联合预测老年AMI患者介入后支架内再狭窄的曲线下面积(AUC)分别为0.833、0.746、0.766、0.857,其中联合预测价值最高。结论血清TIMP-1、Gal-3联合IL-17可提高对老年AMI患者PCI后支架内再狭窄的预测价值。Objective To analyze the predictive value of serum matrix metalloproteinase tissue inhibitor-1(TIMP-1),galactose lectin-3(Gal-3)and interleukin-17(IL-17)on in stent restenosis in elderly patients with acute myocardial infarction(AMI)after percutaneous coronary intervention,so as to provide a basis for the prevention of in stent restenosis.Methods In the prospective cohort study,a total of 105 patients with AMI who were treated in Shangqiu Hospital of Traditional Chinese Medicine from August 2018 to August 2021 were taken as the research objects.After admission,patients were treated with emergency PCI.Three days after surgery,serum levels of TIMP-1,Gal-3,and IL-17 were measured in patients.After discharge,the patients were followed up until August 2022.The incidence of in stent restenosis was evaluated according to the results of coronary angiography,and the predictive value of serum TIMP-1,Gal-3,and IL-17 for in stent restenosis in elderly AMI patients after percutaneous coronary intervention was analyzed.Results The follow-up time was up to August 2022.The incidence of in stent restenosis in 105 elderly patients with AMI was 13.33%.The systolic blood pressure,diastolic blood pressure,fasting blood glucose,serum TIMP-1,Gal-3,and IL-17 levels in stenosis group were higher than those in non stenosis group(P<0.05).Point-biserial correlation analysis showed that serum TIMP-1,Gal-3,and IL-17 were positively correlated with in stent restenosis in elderly AMI patients after intervention(r>0,P<0.05).The receiver operating characteristic(ROC)curve was drawn.The results showed that the area under the curve(AUC)of serum TIMP-1,Gal-3,IL-17 alone and combined in predicting in stent restenosis after intervention in elderly AMI patients was 0.833,0.746,0.766 and 0.857,respectively,among which the combined predictive value was the highest.Conclusion Serum TIMP-1,Gal-3 combined with IL-17 can improve the predictive value of in stent restenosis in elderly patients with AMI after percutaneous coronary intervention.

关 键 词：急性心肌梗死 支架内再狭窄 基质金属蛋白酶组织抑制因子-1 半乳糖凝集素-3 白细胞介素-17 

分 类 号：R542.22[医药卫生—心血管疾病]