原发性甲状腺功能亢进患者血清Elabela水平及临床意义  

Level of Serum Elabela in Patients with Primary Hyperthyroidism and Its Clinical Significance

作　　者：刘慧 朱璞 刘娜 LIU Hui;ZHU Pu;LIU Na(Department of Laboratory Medicine,Shangqiu Third People’s Hospital,Shangqiu 476000,China)

机构地区：[1]商丘市第三人民医院检验科,河南商丘476000

出　　处：《河南医学研究》2025年第4期672-675,共4页Henan Medical Research

摘　　要：目的探讨原发性甲状腺功能亢进患者血清Elabela水平及临床意义。方法选取2019年4月至2020年10月商丘市第三人民医院收治并确诊的130例原发性甲状腺功能亢进患者作为甲状腺功能亢进组,并根据疾病的严重程度分为轻度组(41例)、中度组(47例)、重度组(42例)。另外选取同期来商丘市第三人民医院进行体检的60例健康人作为对照组。采用酶联免疫吸附法检测血清Elabela水平,并进行各组间比较。采用Spearman相关分析探讨血清Elabela与原发性甲状腺功能亢进患者病情严重程度的关系,同时采用多因素logistic回归分析原发性甲状腺功能亢进患者疾病严重程度的影响因素。结果甲状腺功能亢进组游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、Elabela水平高于对照组(P<0.05);对照组促甲状腺素(TSH)水平高于甲状腺功能亢进组(P<0.05)。重度组患者血清Elabela水平高于中度组和轻度组(重度组>中度组>轻度组,P<0.05)。Spearman相关分析结果显示,血清Elabela水平与原发性甲状腺功能亢进疾病严重程度呈正相关(r=0.461,P<0.05)。多因素logistic回归分析显示,高水平FT_(3)、高水平FT_(4)、低水平TSH、高水平Elabela是原发性甲状腺功能亢进患者疾病严重的独立危险因素(P<0.05)。结论原发性甲状腺功能亢进患者血清Elabela表达水平增高,并且与疾病严重程度呈正相关,能够作为评估原发性甲状腺功能亢进疾病严重程度的指标,有一定的临床推广价值。Objective To investigate the serum Elabela level and its clinical significance in patients with primary hyperthyroidism.Methods The 130 patients with primary hyperthyroidism admitted and diagnosed in Shangqiu Third People’s Hospital from April 2019 to October 2020 were selected as the hyperthyroidism group,and then divided into mild group(41 cases),moderate group(47 cases)and severe group(42 cases)according to the severity of the disease.In addition,60 healthy people who came to Shangqiu Third People’s Hospital for physical examination during the same period were selected as the control group.Enzyme-linked immunosorbent assay was used to detect serum Elabela levels,and the level of Elabela between groups were compared.Spearman correlation analysis was used to explore the relationship between serum Elabela and the severity of patients with primary hyperthyroidism,and multivariate logistic regression was used to analyze the influencing factors of the severity of patients with primary hyperthyroidism.Results The levels of free triiodothyronine(FT_(3)),free thyroxine(FT_(4))and Elabela in the hyperthyroidism group were higher than those in the control group(P<0.05),and the thyroid stimulating hormone(TSH)level in the control group was higher than that in the hyperthyroidism group(P<0.05).The serum Elabela level of the severe group was higher than that of the moderate group and the mild group(severe group>moderate group>mild group,P<0.05).The results of Spearman correlation analysis showed that the serum Elabela level was positively correlated with the severity of primary hyperthyroidism(r=0.461,P<0.05).Multivariate logistic regression analysis showed that high level FT_(3),high level FT_(4) and low level TSH and high level of Elabela were independent risk factors for severe disease in patients with primary hyperthyroidism(P<0.05).Conclusion The expression level of serum Elabela in patients with primary hyperthyroidism is increased,and it is positively correlated with the severity of the disease.It can be used as

关 键 词：甲状腺功能亢进 Elabela 临床意义 

分 类 号：R581.1[医药卫生—内分泌]