血清Ficolin-3、尿mAlb/Cr水平对慢性肾小球肾炎患者预后的评估价值  

Prognostic Value of Serum Ficolin-3 and Urinary mAlb/Cr Levels in Patients with Chronic Glomerulonephritis

作　　者：张磊 吴礼选 黄蕊 焦新辉 ZHANG Lei;WU Lixuan;HUANG Rui;JIAO Xinhui(Department of Nephrology,the 987th Hospital of Joint Logistic Support Force of the PLA,Baoji,Shaanxi 721004,China;Department of Acupuncture&Moxibustion,Baoji Hospital of Traditional Chinese Medicine,Baoji,Shaanxi 721004,China;Department of Respiratory&Critical Care Medicine,Baoji High-Tech Hospital,Baoji,Shaanxi 721000,China)

机构地区：[1]联勤保障部队第九八七医院肾脏内科,陕西宝鸡721004 [2]宝鸡市中医医院针灸风湿病科,陕西宝鸡721004 [3]宝鸡市高新医院呼吸及危重症医学科,陕西宝鸡721000

出　　处：《临床误诊误治》2025年第6期33-37,共5页Clinical Misdiagnosis & Mistherapy

基　　金：陕西省医学科学研究课题计划(2018JM2818)。

摘　　要：目的探讨血清纤维胶凝蛋白-3(Ficolin-3)、尿微量白蛋白(mAlb)/肌酐(Cr)水平评估慢性肾小球肾炎(CGN)患者预后的价值。方法回顾性分析2019年1月至2022年1月诊治的CGN患者100例的临床资料,所有患者入院后均接受常规治疗,并对患者进行2年的随访观察评估患者预后情况,将病情无进展/疾病缓解的患者归为预后良好组(n=76),病情进展为慢性肾功能衰竭的患者归为预后不良组(n=24)。统计2组基础资料及估算肾小球滤过率(eGFR),检测血清Ficolin-3水平、尿mAlb/Cr,多因素logistic回归分析CGN患者预后不良的危险因素,绘制受试者工作特征曲线评估血清Ficolin-3水平、尿mAlb/Cr预测CGN患者预后不良的效能。结果预后不良组eGFR显著低于预后良好组,血清Ficolin-3水平及尿mAlb/Cr显著高于预后良好组(P<0.01);eGFR、血清Ficolin-3及尿mAlb/Cr是CGN患者预后不良的危险因素(P<0.05,P<0.01);血清Ficolin-3水平和尿mAlb/Cr均可用于CGN患者预后不良的评估,曲线下面积分别为0.805、0.877(P<0.01)。结论血清Ficolin-3水平和尿mAlb/Cr升高会影响CGN患者预后,且对评估CGN患者预后具有一定价值。Objective To evaluate the prognostic value of serum Ficolin-3 and urinary microalbumin(mAlb)/creatinine(Cr)levels in patients with chronic glomerulonephritis(CGN).Methods Clinical data of 100 CGN patients diagnosed and treated from January 2019 to January 2022 were retrospectively analyzed.All patients received routine treatment after admission,and were followed up for 2 years to evaluate the prognosis of patients.Patients with no progression or remission of disease were classified as the good prognosis group(n=76),and patients with chronic renal failure were classified into the poor prognosis group(n=24).Baseline data and estimated glomerular filtration rate(eGFR)of the two groups were analyzed,serum Ficolin-3 level and urinary mAlb/Cr were detected,and the risk factors of poor prognosis in CGN patients were analyzed by multivariate logistic regression.Receiver operating characteristic(ROC)curves were drawn to evaluate the efficacy of serum Ficolin-3 level and urinary mAlb/Cr in predicting poor prognosis in CGN patients.Results eGFR in poor prognosis group was significantly lower than that in good prognosis group,while serum Ficolin-3 level and urinary mAlb/Cr in poor prognosis group were significantly higher than those in good prognosis group(P<0.01).eGFR,and serum Ficolin-3 and urinary mAlb/Cr were risk factors for poor prognosis in CGN patients(P<0.05,P<0.01).Both serum Ficolin-3 level and urinary mAlb/Cr could be used to evaluate the poor prognosis of CGN patients,and the area under the ROC curve was 0.805 and 0.877,respectively(P<0.01).Conclusion The increase of serum Ficolin-3 level and urinary mAlb/Cr can affect the prognosis of CGN patients,and it is of certain value in evaluating the prognosis of CGN patients.

关 键 词：慢性肾小球肾炎 尿微量白蛋白/肌酐 纤维胶凝蛋白-3 估算肾小球滤过率 危险因素 预后 受试者工作特征 

分 类 号：R692.31[医药卫生—泌尿科学]