超声血流参数、血清SCC-Ag水平联合检测对子宫内膜癌患者预后的预测价值  

Prognostic value of combined detection of ultrasonic blood flow parameters and serum SCC-Ag level in patients with endometrial cancer

作　　者：肖四华 邓仝彤 XIAO Sihua;DENG Tongtong(Department of Ultrasound Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属郑州中心医院超声医学科,河南郑州450000

出　　处：《黑龙江医药科学》2025年第2期77-80,85,共5页Heilongjiang Medicine and Pharmacy

摘　　要：目的:探讨子宫内膜癌患者超声血流参数、血清鳞状细胞癌抗原(SCC-Ag)水平变化,并分析其联合检测对预后的预测价值。方法:回顾性选取2021年1月至2023年1月于郑州大学附属郑州中心医院诊治的子宫内膜癌患者126例作为研究组,另选取同期子宫内膜增生患者42例作为对照组。比较两组超声血流参数、血清SCC-Ag水平。研究组予以常规方案治疗,依据治疗后1年内预后情况分为预后不良31例、预后良好95例,比较其治疗前后超声血流参数、血清SCC-Ag水平变化。分析预后不良的影响因素。评价治疗后超声血流参数、血清SCC-Ag水平对预后的预测价值,并分析其评估预后不良发生风险的净受益率。结果:研究组搏动指数(PI)、阻力指数(RI)低于对照组,收缩期峰值流速(PSV)及血清SCC-Ag水平高于对照组(P<0.05);预后不良者治疗后PI、RI低于预后良好者,PSV及血清SCC-Ag水平高于预后良好者(P<0.05);临床分期、淋巴结转移及治疗后3个月PSV、血清SCC-Ag水平为预后不良的独立危险因素,分化程度及治疗后3个月PI、RI为预后不良的独立保护因素(P<0.05);治疗后3个月PI、RI、PSV、SCC-Ag联合预测预后不良的AUC大于单项指标预测(P<0.05);当风险阈值为0~0.5时,治疗后3个月PI、RI、PSV、SCC-Ag联合检测的净受益率>单项指标检测。结论:子宫内膜癌患者PI、RI降低,PSV及血清SCC-Ag水平升高,且为预后不良的影响因素,联合检测其水平对预后具有一定预测价值。Objective:To investigate the changes in ultrasonic blood flow parameters and serum squamous cell carcinoma antigen(SCC-Ag)levels in patients with endometrial cancer and analyze their predictive value for prognosis.Methods:A retrospective study was conducted on 126 patients with endometrial cancer diagnosed and treated at Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2021 to January 2023,who were selected as the study group.Additionally,42 patients with endometrial hyperplasia during the same period were selected as the control group.The ultrasonic blood flow parameters and serum SCC-Ag levels were compared between the two groups.The study group received conventional treatment and was divided into a poor prognosis group of 31 patients and a good prognosis group of 95 patients based on their prognosis within one year after treatment.The changes in ultrasonic blood flow parameters and serum SCC-Ag levels before and after treatment were compared between the two prognosis groups.The influencing factors of poor prognosis were analyzed.The predictive value of ultrasonic blood flow parameters and serum SCC-Ag levels for prognosis after treatment was evaluated,and the net benefit rate of these parameters in assessing the risk of poor prognosis was analyzed.Results:The pulsatility index(PI)and resistance index(RI)were lower in the study group than in the control group,while the peak systolic velocity(PSV)and serum SCC-Ag levels were higher(P<0.05).After treatment,patients with poor prognosis had lower PI and RI and higher PSV and serum SCC-Ag levels compared to those with good prognosis(P<0.05).Clinical stage,lymph node metastasis and PSV and serum SCC-Ag levels three months after treatment were independent risk factors for poor prognosis,while differentiation degree,PI and RI three months after treatment were independent protective factors for poor prognosis(P<0.05).The area under the curve(AUC)for combined prediction of poor prognosis using PI,RI,PSV and SCC-Ag three months after treatment wa

关 键 词：子宫内膜癌 超声血流参数 鳞状细胞癌抗原 预后 预测 

分 类 号：R445[医药卫生—影像医学与核医学] R737[医药卫生—诊断学]