高压氧治疗急性一氧化碳中毒预后的影响因素分析  

Analysis of prognostic factors of hyperbaric oxygen therapy for acute carbon monoxide poisoning

作　　者：章桂霞 王国兴 王霞 季红 李轩利 ZHANG Guixia;WANG Guoxing;WANG Xia;JI Hong;LI Xuanli(Department of Hyperbaric Oxygen,Nanjing Zijin Hospital,Jiangsu Province,Nanjing 210001,China;Department of Neurological Rehabilitation,Nanjing Zijin Hospital,Jiangsu Province,Nanjing 210001,China)

机构地区：[1]南京紫金医院高压氧科,江苏南京210001 [2]南京紫金医院神经康复科,江苏南京210001

出　　处：《中国当代医药》2025年第5期39-43,共5页China Modern Medicine

摘　　要：目的探讨影响高压氧治疗急性一氧化碳中毒预后的相关因素。方法回顾性选取2014年1月至2017年5月南京紫金医院收治的95例急性一氧化碳中毒患者作为研究对象,根据预后将其分为观察组(67例)与对照组(28例),观察组符合治愈标准,对照组符合好转或无效标准。结果单因素分析结果显示,急性一氧化碳中毒的预后与年龄、中毒程度、高压氧开始治疗时间、高压氧治疗次数有关,差异有统计学意义(P<0.05)。logistic回归模型进行多因素分析结果显示,中毒程度(β=1.2674,OR=3.5516,95%CI:1.5093~8.3573)、高压氧开始治疗时间(β=1.0593,OR=2.8844,95%CI:1.0810~7.6958)是影响急性一氧化碳中毒预后的独立危险因素(P<0.05),而高压氧治疗次数(β=-1.1319,OR=0.3224,95%CI:0.1280~0.8122)则是影响急性一氧化碳中毒预后的独立保护因素(P<0.05)。结论高压氧治疗急性一氧化碳中毒应尽早实施,并且根据病情尽可能多地增加高压氧治疗次数,从而最大程度地改善患者预后。Objective To explore the prognostic factors of hyperbaric oxygen therapy for acute carbon monoxide poisoning.Methods A total of 95 patients with acute carbon monoxide poisoning admitted to Nanjing Zijin Hospital from January 2014 to May 2017 were retrospectively selected as the research objects.According to the prognosis,they were divided into observation group(67 cases)and control group(28 cases).The observation group met the criteria of cure,and the control group met the criteria of improvement or ineffective.Results The results of univariate analysis showed that the prognosis of acute carbon monoxide poisoning was related to age,degree of poisoning,time of starting hyperbaric oxygen treatment and frequency of hyperbaric oxygen treatment,and the differences were statistically significant(P<0.05).Multivariate analysis by logistic regression model showed that the degree of poisoning(β=1.2674,OR=3.5516,95%CI:1.5093-8.3573)and the time of starting hyperbaric oxygen treatment(β=1.0593,OR=2.8844,95%CI:1.0810-7.6958)were independent risk factors for the prognosis of acute carbon monoxide poisoning(P<0.05),while the frequency of hyperbaric oxygen treatment(β=-1.1319,OR=0.3224,95%CI:0.1280-0.8122)was independent protective factor for the prognosis of acute carbon monoxide poisoning(P<0.05).Conclusion Hyperbaric oxygen therapy for acute carbon monoxide poisoning should be implemented as early as possible,and the frequency of hyperbaric oxygen therapy should be increased as much as possible according to the condition,so as to improve the prognosis of patients to the greatest extent.

关 键 词：高压氧 急性一氧化碳中毒 预后 相关因素 

分 类 号：R459.6[医药卫生—治疗学]