纤维支气管镜肺泡灌洗联合甲泼尼龙治疗儿童重症肺炎支原体肺炎的临床效果  

Clinical effect of bronchoscopic alveolar lavage combined with Methylprednisolone in treatment of severe mycoplasma pneumonia in children

作　　者：林雯 周明建 吴燕成 LIN Wen;ZHOU Mingjian;WU Yancheng(Department of Child Healthcare,Ningde Maternal and Child Health Hospital,Fujian Province,Ningde352100,China;Department of Pediatrics,Ningde Hospital Affiliated to Ningde Normal University,Fujian Province,Ningde352100,China)

机构地区：[1]福建省宁德市妇幼保健院儿保科,福建宁德352100 [2]宁德师范学院附属宁德市医院儿科,福建宁德352100

出　　处：《中国当代医药》2025年第5期92-95,共4页China Modern Medicine

摘　　要：目的探讨采用纤维支气管镜肺泡灌洗联合甲泼尼龙治疗儿童重症支原体肺炎的效果。方法回顾性分析2020年10月至2024年4月宁德师范学院附属宁德市医院儿科收治的50例重症肺炎支原体肺炎患儿的临床资料,按照治疗方法不同分为对照组和观察组,每组25例。对照组采用常规治疗加用甲泼尼龙静脉滴注治疗,观察组在对照组治疗的基础上加用纤维支气管镜肺泡灌洗治疗。比较两组患儿的治疗总有效率、临床症状、炎症因子水平。结果治疗10 d后,观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组发热、咳嗽、胸痛、肺部啰音等临床症状消失的时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组患儿炎症因子水平比较,差异无统计学意义(P>0.05);治疗后,两组患儿降钙素原、白细胞介素-6、C反应蛋白水平均低于本组治疗前,且观察组降钙素原、白细胞介素-6、C反应蛋白水平低于对照组,差异有统计学意义(P<0.05)。结论在常规治疗的基础上采用纤维支气管镜肺泡灌洗联合甲泼尼龙治疗儿童重症肺炎支原体肺炎的总有效率较高,缩短临床症状改善时间,提高炎症因子水平下降程度,效果优于常规治疗加用单纯甲泼尼龙静脉滴注治疗。Objective To investigate the effect of bronchoscopic alveolar lavage combined with Methylprednisolone in the treatment of severe mycoplasma pneumonia in children.Methods The clinical data of 50 children with severe mycoplasma pneumonia admitted to the Department of Pediatrics of Ningde Hospital Affiliated to Ningde Normal University from October 2020 to April 2024 were retrospectively analyzed,and they were divided into control group and observation group according to different treatment methods,with 25 cases in each group.The control group was treated with conventional treatment combined with Methylprednisolone intravenous infusion,and the observation group was treated with bronchoscopic alveolar lavage on the basis of the control group.The total effective rate,clinical symptoms and inflammatory factors were compared between the two groups.Results After 10 days of treatment,the total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The time for clinical symptoms such as fever,cough,chest pain and lung rales to disappear in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of inflammatory factors between the two groups(P>0.05).After treatment,the levels of procalcitonin,interleukin-6 and C-reactive protein in two groups were lower than those before treatment,and the levels of procalcitonin,interleukin-6 and C-reactive protein in observation group were lower than those in control group,with statistical significances(P<0.05).Conclusion Based on conventional treatment,bronchoscopic alveolar lavage combined with Methylprednisolone in the treatment of severe mycoplasma pneumonia in children has higher total effective rate,shorting the improvement time of clinical symptoms and increasing the levels of inflammatory factors,and the effect is better than conventional treatment combined with Meth

关 键 词：重症支原体肺炎 甲泼尼龙 纤维支气管镜 肺泡灌洗 疗效 

分 类 号：R725.6[医药卫生—儿科]