血清sCD14联合sCD30对老年慢性阻塞性肺疾病合并肺部真菌感染的诊断价值  

Diagnostic Value of Serum sCD14 Combined with sCD30 in Elderly Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Fungal Infection

作　　者：杨建华 YANG Jianhua(Department of Internal Medicine,the Fifth People's Hospital of Taizhou,Taizhou Jiangsu 225300)

机构地区：[1]泰州市第五人民医院内科,江苏泰州225300

出　　处：《医学临床研究》2025年第2期225-227,231,共4页Journal of Clinical Research

摘　　要：【目的】探讨血清可溶性白细胞分化抗原14(sCD14)联合sCD30对老年慢性阻塞性肺疾病(COPD)合并肺部真菌感染的诊断价值。【方法】选取2021年4月至2023年6月本院收治的80例老年COPD患者,以真菌培养为金标准,将患者分为A组(n=23,合并肺部真菌感染)和B组(n=57,未合并肺部真菌感染),采用酶联免疫吸附法检测两组患者入院第2天血清sCD14、sCD30水平,分析老年COPD合并肺部真菌感染的影响因素及血清sCD14、sCD30诊断老年COPD合并肺部真菌感染的效能。【结果】A组急性生理学与慢性健康状况评价Ⅱ(APACHEⅡ)评分及sCD14、sCD30、C反应蛋白(CRP)水平均高于B组(P<0.05)。二元Logistic回归分析显示:APACHEⅡ评分及sCD14、sCD30、CRP水平高是老年COPD患者发生肺部真菌感染的危险因素(P<0.05)。APACHEⅡ评分联合血清sCD14、sCD30、CRP检测诊断老年COPD患者合并肺部真菌感染的效能均高于单一指标检测。【结论】APACHEⅡ评分联合血清sCD14、sCD30、CRP检测诊断老年COPD合并肺部真菌感染的临床价值较高。【Objective】To investigate the diagnostic value of serum soluble 14(sCD14)combined with sCD30 in elderly patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary fungal infection.【Methods】A total of 80 elderly patients with COPD admitted to our hospital from April 2021 to June 2023 were selected and divided into group A(n=23,combined with pulmonary fungal infection)and group B(n=57,not combined with pulmonary fungal infection),using fungal culture as the gold standard.Serum sCD14 and sCD30 levels were detected by ELISA on the second day of admission in the two groups,and the influencing factors of senile COPD combined with pulmonary fungal infection and the efficacy of serum sCD14 and sCD30 in diagnosis of senile COPD combined with pulmonary fungal infection were analyzed.【Results】The Acute physiology and Chronic Health status Scoring SystemⅡ(APACHEⅡ)scores and the levels of sCD14,sCD30 and C-reactive protein(CRP)in group A were higher than those in group B(P<0.05).Binary Logistic regression analysis showed that APACHEⅡscore and high levels of sCD14,sCD30 and CRP were risk factors for pulmonary fungal infection in elderly patients with COPD(P<0.05).APACHEⅡscore combined with serum sCD14,sCD30 and CRP were more effective than single index in predicting pulmonary fungal infection in elderly patients with COPD.【Conclusion】APACHEⅡscore combined with serum sCD14,sCD30 and CRP has a high predictive value for pulmonary fungal infection in elderly patients with COPD.

关 键 词：肺疾病 慢性阻塞性 肺疾病 真菌性 脂多糖受体 

分 类 号：R563[医药卫生—呼吸系统]