维生素B_(12)和叶酸治疗巨幼细胞贫血患者的临床疗效  

Clinical Efficacy of Vitamin B_(12)and Folic Acid in the Treatment of Megaloblastic Anemia Patients

作　　者：孙兴卫[1] SUN Xingwei(Department of Hematology and Oncology,Zhengzhou Second People's Hospital,Zhengzhou Henan 450000)

机构地区：[1]郑州市第二人民医院血液肿瘤科,河南郑州450000

出　　处：《医学临床研究》2025年第2期255-257,共3页Journal of Clinical Research

摘　　要：【目的】探讨维生素B_(12)和叶酸治疗巨幼细胞贫血(MA)患者的临床疗效。【方法】收集50例采用维生素B_(12)和叶酸补充治疗的MA患者的临床资料,分析患者的临床表现,血液学指标的变化和治疗效果。【结果】治疗后,患者的平均红细胞体积(MCV)较治疗前降低,血红蛋白(Hb)、维生素B_(12)、叶酸水平较治疗前升高,且差异均有统计学意义(P<0.05)。治疗后,乏力、面色苍白、食欲不振、体重下降、有神经症状的患者的比例较治疗前明显降低,差异有统计学意义(P<0.05)。相关性分析显示,维生素B_(12)与症状改善的关联最为密切,维生素B_(12)、叶酸、Hb水平与乏力、面色苍白、食欲不振、体重下降、神经症状均呈负相关(P<0.05)。MCV与上述症状均呈正相关(P<0.05)。【结论】维生素B_(12)和叶酸的补充治疗可以改善MA患者的血液学指标和临床症状,其中,维生素B_(12)在症状改善中发挥了关键作用,临床在诊治MA时,应重视维生素B_(12)水平的检测和补充。【Objective】To explore the clinical efficacy of vitamin B_(12)and folic acid in the treatment of megaloblastic anemia(MA)patients.【Methods】Clinical data of 50 MA patients treated with vitamin B_(12)and folic acid supplementation were collected.The patients'clinical manifestations,changes in hematological indicators,and treatment outcomes were analyzed.【Results】After treatment,the mean corpuscular volume(MCV)of the patients decreased,while hemoglobin(Hb),vitamin B_(12),and folic acid levels increased significantly compared to before treatment,with differences being statistically significant(P<0.05).The proportion of patients with symptoms such as fatigue,pallor,loss of appetite,weight loss,and neurological symptoms significantly decreased after treatment,with differences being statistically significant(P<0.05).Correlation analysis showed that vitamin B_(12)had the closest association with symptom improvement.Vitamin B_(12),folic acid,and Hb levels were negatively correlated with fatigue,pallor,loss of appetite,weight loss,and neurological symptoms(all P<0.05).MCV was positively correlated with the above symptoms(P<0.05).【Conclusion】Supplementation of vitamin B_(12)and folic acid can improve hematological indicators and clinical symptoms in MA patients,which vitamin B_(12)plays a key role in symptom improvement.When diagnosing and treating MA clinically,attention should be paid to the detection and supplementation of vitamin B_(12)levels.

关 键 词：贫血 巨幼细胞性 维生素B_(12) 叶酸 治疗结果 

分 类 号：R556[医药卫生—血液循环系统疾病]