非剥脱点阵激光联合非那雄胺、米诺地尔酊治疗雄性激素源性脱发男性患者的临床疗效  

Clinical Effect of Non-stripping Dot Matrix Laser Combined with Finasteride and Minoxidil Tincture on Male Patients with Androgenic Alopecia

作　　者：杨晓娟 YANG Xiaojuan(Department of Dermatology,The Third People's Hospital of Puyang,Puyang Henan 457000)

机构地区：[1]濮阳市第三人民医院皮肤科,河南濮阳457000

出　　处：《医学临床研究》2025年第2期282-285,共4页Journal of Clinical Research

摘　　要：【目的】探讨非剥脱点阵激光联合非那雄胺、米诺地尔酊治疗雄激素源性脱发患者的疗效。【方法】选取2022年1月至2023年12月本院收治的80例雄激素源性脱发男性患者,按照随机数字表法分为对照组(采用非那雄胺、米诺地尔酊治疗)和观察组(采用非剥脱点阵激光联合非那雄胺、米诺地尔酊治疗),每组40例。比较两组临床疗效、毛发生长情况(毛发密度、毛发粗度、空毛囊比例)、毛发镜下征象(大于20%的毛发直径变细、蜂窝状色素沉着、局部无毛征、白色鳞屑、褐色毛周征、黄点征、白点征)、不良反应发生情况。【结果】观察组总有效率高于对照组(P<0.05)。治疗后,两组毛发密度大于治疗前,空毛囊比例低于治疗前(P<0.05),且观察组毛发密度大于对照组,空毛囊比例低于对照组(P<0.05);两组治疗前后毛发粗度比较,差异无统计学意义(P>0.05)。治疗后,观察组大于20%的毛发直径变细、局部无毛征、黄点征占比均低于对照组(P<0.05),两组蜂窝状色素沉着、白色鳞屑、褐色毛周征、白点征情况比较,差异无统计学意义(P>0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】非剥脱点阵激光联合非那雄胺、米诺地尔酊治疗雄激素源性脱发男性患者具有良好的疗效,可改善患者毛囊生理情况,促进毛发生长,且具有良好的安全性,值得临床推广应用。【Objective】To investigate the effect of non-exfoliating dot matrix laser combined with finasteride and minoxidil tincture in the treatment of androgenic alopecia.【Methods】A total of 80 male patients with androgenic alopecia admitted to our hospital from January 2022 to December 2023 were selected and divided into the control group(treated with finasteride and minoxidil tincture)and the observation group(treated with non-stripping dot matrix laser combined with finasteride and minoxidil tincture)according to random number table method,with 40 cases in each group.The clinical efficacy,hair growth(hair density,hair thickness,proportion of empty hair follicles),trichoscopic signs(hair diameter thinning>20%,cellular pigmentation,local absence of hair,white scale,brown peri-hair sign,yellow dot sign,white dot sign)and adverse reactions were compared between the two groups.【Results】The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the hair density of the two groups was higher than before treatment,and the proportion of empty hair follicles was lower than before treatment(P<0.05).The hair density of the observation group was higher than that of the control group,and the proportion of empty hair follicles was lower than that of the control group(P<0.05).There was no statistical significance in hair coarseness between the two groups before and after treatment(P>0.05).After treatment,the proportion of hair diameter finer,local no hair sign and yellow dot in observation group was lower than that in control group(P<0.05).There was no statistical significance in the situation of honeycomb pigmentation,white scale,brown peri-hair sign and white dot sign between the two groups(P>0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】Non-stripping dot matrix laser combined with finasteride and minoxidil tincture in the treatment of male patients with androgenic alopecia has a

关 键 词：秃发 激光 雄甾烯类 米诺地尔 治疗结果 

分 类 号：R753.32[医药卫生—皮肤病学与性病学]