多西环素、硫酸羟氯喹联合光电协同技术治疗面部玫瑰痤疮的临床研究  

Clinical study of doxycycline,hydroxychloroquine sulfate combined with photoelectric synergism in the treatment of facial rosacea

作　　者：陈龙 郑桂芳 CHEN Long;ZHENG Guifang(Department of Pharmacy,Fuqing Institute of Dermatology,Fuqing 350300,Fujian Province,China;Department of Dermatology,Fuqing Institute of Dermatology,Fuqing 350300,Fujian Province,China)

机构地区：[1]福清市皮肤病防治院药剂科,福建福清350300 [2]福清市皮肤病防治院皮肤科,福建福清350300

出　　处：《中国医疗美容》2025年第2期5-8,共4页China Medical Cosmetology

摘　　要：目的分析多西环素、硫酸羟氯喹联合光电协同技术治疗面部玫瑰痤疮的疗效。方法选取2022年1月至2023年12月福清市皮肤病防治院接收的100例玫瑰痤疮患者,按照治疗方法的不同分为观察组和对照组,各50例,对照组患者口服多西环素、硫酸羟氯喹治疗。观察组患者在口服药物的基础上加用光电协同技术治疗。比较两组患者治疗总有效率、治疗前后皮肤角质层含水量、经皮水分丢失、表皮皮脂含量和生活质量指数改善情况、不良反应发生率。结果观察组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后观察组患者皮肤角质层含水量、经皮水分丢失、表皮皮脂含量等皮肤指标水平与和生活质量指数均优于对照组,差异有统计学意义(P<0.05),两组玫瑰痤疮患者面部泛红、干燥、色素沉着等不良反应比较,差异无统计学意义(P>0.05)。结论多西环素、硫酸羟氯喹联合光电协同技术治疗玫瑰痤疮的疗效良好,有利于改善皮肤生理状况,提升患者生活质量,安全性高。Objective To analysis of the therapeutic effect of doxycycline,hydroxychloroquine sulfate combined with photoelectronic synergistic technology in the treatment of facial rosacea.Methods Select 100 patients with rosacea admitted to Fuqing Dermatology Prevention and Treatment Hospital from January 2022 to December 2023,and divide them into an observation group and a control group according to different treatment methods,with 50 patients in each group.Patients in the control group are treated with oral doxycycline and hydroxychloroquine sulfate.Observation group patients were treated with photoelectric synergistic technology in addition to oral medication.Compare the total effective rate of treatment,the moisture content of the stratum corneum before and after treatment,the loss of transdermal moisture,the improvement of epidermal sebum content and quality of life index,and the incidence of adverse reactions between two groups of patients.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of non-invasive physiological indicators such as skin stratum corneum water content,transdermal water loss,and epidermal sebum content in the observation group were better than those in the control group,and the quality of life index were statistically signifificant(P<0.05).There was no statistically signifificant difference in adverse reactions such as facial redness,dryness,and pigmentation between the two groups of patients with rosacea(P>0.05).Conclusions The combination of oral doxycycline,hydroxychloroquine sulfate,and photoelectronic synergistic technology has shown good effificacy in treating rosacea,which is benefificial for improving the physiological condition of the skin,enhancing the quality of life of patients,and has high safety.

关 键 词：多西环素 硫酸羟氯喹 光电协同技术 玫瑰痤疮 

分 类 号：R758.734[医药卫生—皮肤病学与性病学]