5-氨基酮戊酸光动力疗法联合盐酸米诺环素治疗聚合性痤疮的临床疗效观察  

Therapeutic effect of 5-aminolevulinic acid photodynamic therapy combined with minocycline hydrochloride on the patients with acne conglobata

作　　者：肖汉龙[1] 孙江华[1] 王军[1] 石璇 方于民 XIAO Hanlong;SUN Jianghua;WANG Jun;SHI Xuan;FANG Yumin(Department of Dermatology,Hubei Provincial Corps Hospital,Chinese People's Armed Police Forces,Wuhan 430061,Hubei Province,China)

机构地区：[1]武警湖北省总队医院皮肤科,湖北武汉430061

出　　处：《中国医疗美容》2025年第2期8-11,共4页China Medical Cosmetology

基　　金：湖北省卫生健康委面上项目(项目编号:WJ2023M093)。

摘　　要：目的观察5-氨基酮戊酸光动力疗法联合盐酸米诺环素治疗聚合性痤疮的临床疗效与安全性。方法选取2021年55月至2024年5月武警湖北省总队医院收治的90例聚合性痤疮患者,按治疗方法不同分为3组,每组30例,所有患者疗程均为4周。治疗组给予5-氨基酮戊酸光动力疗法联合盐酸米诺环素口服;对照一组患者给予5-氨基酮戊酸光动力疗法;对照二组患者给予盐酸米诺环素口服。3组患者均在治疗开始后的第4周和第8周评定疗效。结果治疗4周后治疗组和对照一组患者的有效率分别为46.7%和33.3%,对照二组患者的有效率为6.7%;治疗组和对照一组患者的有效率均分别显著高于对照二组的有效率。治疗8周后治疗组患者的有效率为76.7%,对照一组患者的有效率为40.0%;两组比较,差异有统计学意义(P<0.05)。治疗组患者在治疗8周后的有效率也显著高于治疗4周后的有效率。治疗过程中不良反应少见且患者均可耐受。结论5-氨基酮戊酸光动力疗法联合盐酸米诺环素治疗聚合性痤疮疗效确切,值得临床推广应用。Objective To observe the efficacy of 5-aminolevulinic acid photodynamic therapy(5-ALA-PDT)combined with minocycline hydrochloride on the patients with acne conglobata.Methods 90 patients with acne conglobata in Hubei Provincial Corps Hospital,Chinese People's Armed Police Forces were selected from May 2021 to May 2024.All the patients were divided into three groups(30 cases each group)due to different treatments and the course of treatment in all groups was 4 weeks.The patients of treatment group were treated by both 5-ALA-PDT and minocycline hydrochloride while control 1 group and control 2 group were treated by 5-ALA-PDT and minocycline hydrochloride respectively.The clinical effects were observed after 4 weeks and 8 weeks of treatment.Results After 4 weeks of treatment,the effective rates of treatment group and control 1 group were 46.7%and 33.3%,which were both signifificantly higher than that of control 2 group(6.7%).After 8 weeks of treatment,the effective rates of treatment group and control 1 group were 76.7%and 40.0%;which showed a signifificant difference between them(P<0.05).Besides,in the patients of treatment group,the effective rate after 8 weeks of treatment was signifificantly higher than that after 4 weeks of treatment.The adverse reactions were mild and could be tolerated.Conclusions 5-ALA-PDT combined with minocycline hydrochloride is effective in the treatment on the patients with acne conglobata.This method is recommended for clinical promotion and application.

关 键 词：聚合性痤疮 5-氨基酮戊酸 光动力疗法 盐酸米诺环素 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]