自体富血小板血浆联合二氧化碳点阵激光治疗稳定期白癜风的疗效观察  

Therapeutic efficacy of autologous platelet-rich plasma combined with CO_(2)fractional laser in the treatment of stable vitiligo

作　　者：罗增香 庞云燕 孙瑞萍 孟慧娟 袁相凤 LUO Zengxiang;PANG Yunyan;SUN Ruiping;MENG Huijuan;YUAN Xiangfeng(Department of Dermatology,Affifiliated Hospital of Shandong Second Medical University,Weifang 261000,Shandong Province,China)

机构地区：[1]山东第二医科大学附属医院皮肤科,山东潍坊261000

出　　处：《中国医疗美容》2025年第2期21-25,共5页China Medical Cosmetology

基　　金：潍坊市科技发展计划项目(2023YX051)。

摘　　要：目的探讨采用自体富血小板血浆微针注射联合二氧化碳(CO_(2))点阵激光治疗稳定期白癜风的疗效。方法选取2022年2月至2024年12月潍坊医学院附属医院收治且符合研究开展条件的80例稳定期白癜风患者展开前瞻性研究。按照治疗方法不同将患者分为4组,分别为对照组和观察1组、观察2组、观察3组,对照组患者行窄谱中波紫外线(NB-UVB)治疗,观察1组行CO_(2)点阵激光联合自体富血小板血浆(PRP)微针注射及NB-UVB治疗,观察2组行CO_(2)点阵激光联合NB-UVB治疗,观察3组行PRP联合NU-UVB治疗。观察与评估组间疗效,同时观察治疗前后血清TGF-β、IL-6、IL-17、IL-23等免疫、炎症因子水平变化,并统计不良反应发生率。结果观察1组患者总有效率高于对照组和观察2、3组,差异有统计学意义(χ^(2)=14.949,P=0.002)。观察1组患者TGF-β水平高于对照组和观察2、3组,IL-6、IL-17、IL-23水平低于对照组和观察2、3组,差异有统计学意义(P<0.05)。4组患者不良反应比较,差异无统计学意义(χ^(2)=0.784,P=0.853)。结论针对稳定期白癜风患者,采用PRP联合CO_(2)点阵激光治疗可发挥协同效应,有助于进一步抑制免疫反应,减轻炎症反应,继而增强疗效,是一种安全、有效的治疗选择。Objective To investigate the value of using autologous platelet-rich plasma combined with CO_(2)fractional laser for the treatment of stable vitiligo.Methods A total of 80 cases of stable vitiligo patients admitted to the Affifiliated Hospital of Weifang Medical College from February 2022 to December 2024 and meeting the conditions of the study were selected for prospective study.According to the principle of randomized numerical table grouping,the enrolled patients were divided into four groups,respectively,the control group and observation group 1,2 and 3,the control group was treated with narrow-spectrum medium-wave ultraviolet light,observation group 1 was treated with CO_(2)fractional laser+autologous platelet-rich plasma microneedle injection+NB-UVB therapy,observation group 2 was treated with individual CO_(2)fractional laser therapy+NB-UVB,and observation group 3 was treated with PRP+NUUVB therapy.The effificacy of the two groups was observed and evaluated,and changes in the levels of serum TGF-β,IL-6,IL-17,IL-23 and other immune and inflflammatory factors before and after treatment were also observed,and the incidence of adverse reactions was counted.Results The total effective rate of observation 1 group was higher than that of control group and observation 2 and 3 groups(χ^(2)=14.949,P=0.002).The TGF-βlevel of observation group 1 was higher than that of control group and observation groups 2 and 3,and the levels of IL-6,IL-17,and IL-23 were lower than those of control group and observation groups 2 and 3(P<0.05).The difference of adverse reactions among the four groups was not statistically signifificant(χ^(2)=0.784,P=0.853).Conclusions For patients with stable vitiligo,the use of PRP combined with CO_(2)fractional laser treatment can exert a synergistic effect,which helps to further inhibit the immune response,reduce the inflflammatory response,and then enhance the therapeutic effect,which is a safe and effective treatment choice.

关 键 词：白癜风 稳定期 窄谱中波紫外线 CO_(2)点阵激光 自体富血小板血浆微针 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]