成血管-成骨耦联相关因子在骨缺损中的研究进展  

Research progress of osteogenic and angiogenic coupling factors in bone defects

作　　者：朱甜甜 吾西坤·吾然 何惠宇[1,2] ZHU Tiantian;Wuxikun·Wuran;HE Huiyu(Department of Prosthodontics and Implantology,The First Affiliated Hospital of Xinjiang Medical University(Affiliated Stomatological Hospital),Urumqi 830054,Xinjiang Uygur Autonomous Region,China;Institute of Stomatology,Xinjiang Autonomous Region,Urumqi 830054,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆医科大学第一附属医院(附属口腔医院)口腔修复种植科,新疆乌鲁木齐830054 [2]新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐830054

出　　处：《中国医疗美容》2025年第2期99-102,共4页China Medical Cosmetology

基　　金：新疆维吾尔自治区科技支疆计划项目(2022E02043)。

摘　　要：血管生成与骨生成之间复杂的空间和时间关系被称为“成血管-成骨耦联”。血管生成对骨形成过程很重要,成血管-成骨不平衡会导致局部骨组织过度矿化或血管肿块。血管的侵入是骨形成的先决条件,二者相互耦联是骨形成的关键因素,血管不仅为骨组织提供营养、运输氧气、生长因子及代谢废物,还通过血管内皮生长因子、血管生成素等,对血管与骨形成的各阶段起调控作用。近年来随着组织工程的广泛研究,拓宽了成血管-成骨耦联相关信号分子在骨组织工程中的作用。本文拟通过对相关研究成果进行综述,以期为血管化组织工程骨提供思路。The complex spatial and temporal relationship between angiogenesis and osteogenesis has been termed"angiogenicosteogenic coupling".Angiogenesis is important for the bone formation process,and an angiogenic-osteogenic imbalance can lead to local mineralisation of bone tissue or vascular masses.The invasion of blood vessels is a prerequisite for bone formation,and their mutual coupling is a key factor in bone formation.Blood vessels not only provide nutrients,transport oxygen,growth factors and metabolic wastes for bone tissues,but also play a regulatory role in the various stages of vascularity and bone formation through vascular endothelial growth factor,angiopoietin,and so on.With the extensive research on tissue engineering in recent years,the role of vasculogenic-osteogenic coupling-related molecules in bone tissue engineering has been broadened.This paper intends to provide ideas for vascularisation of tissue-engineered bone by reviewing the relevant research results.

关 键 词：生长因子 血管生成 骨生成 组织工程骨 

分 类 号：R68[医药卫生—骨科学]