基于数据挖掘探索杨志旭教授中药治疗脓毒症胃肠功能障碍的经验  

Exploration of Professor YANG Zhixu’s experience for the treatment of sepsis induced acute gastrointestinal injury with traditional Chinese medicine based on data mining technology

作　　者：盛松 陈曼玉 高洪阳 张蕾[1] 宋烨闻 黄烨[1] SHENG Song;CHEN Manyu;GAO Hongyang;ZHANG Lei;SONG Yewen;HUANG Ye(Department of Emergency,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China;Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院西苑医院急诊科,北京100091 [2]北京中医药大学研究生院,北京100029

出　　处：《药学前沿》2025年第2期291-299,共9页China Pharmacist

基　　金：中国中医科学院科技创新工程项目(C12021A02905)。

摘　　要：目的基于数据挖掘方法探索杨志旭教授治疗脓毒症胃肠功能障碍(S-AGI)的临床用药规律。方法纳入杨教授2020年1月1日至2023年12月31日在中国中医科学院西苑医院ICU查房时治疗S-AGI的中药处方,进行四气、五味、归经和功效分类频次分析、关联规则、Phi相关性系数、因子分析、层次聚类分析、复杂网络分析和网络拓扑分析。结果纳入的202张处方中总体用药平和,以寒、温和甘、苦、辛为主,归经以肺、胃、脾、肾、心、肝、大肠为主,功效分类中以补虚药、清热药、化痰止咳平喘药为主,其次为利水渗湿药、解表药、祛风湿药、安神药、化湿药、理气药、活血化瘀药、收涩药、开窍药、消食药、温里药和平肝息风药。关联规则和Phi相关性分析结果符合杨教授补虚扶正、清热化痰、理气化湿的总治疗原则。因子分析及聚类分析得出7个公因子和7类组方,体现了杨教授注重开宣肺气、补脾益气、安神定志和随证灵活化裁的用药特色。复杂网络分析和拓扑分析显示核心治疗药物是黄芪、白术、瓜蒌、金银花、茯苓和生地黄。结论杨教授治疗S-AGI用药平和,以补虚扶正、清热化痰、理气化湿为主要治法,注重开宣肺气、补脾益气、安神定志和随证灵活化裁。Objective To explore Professor YANG Zhixu’s clinical medication experience for the treatment of sepsis induced acute gastrointestinal injury(S-AGI)based on data mining technology.Methods The prescriptions of S-AGI written by Professor Yang in the ICU of Xiyuan Hospital of China Academy of Chinese Medical Sciences from January 1st 2020 to December 31st 2023 were included.Data analysis involved the frequency of the four properties,the five flavors,meridian tropism and efficacy classification,the association rules,Phi coefficient,factor analysis,hierarchical clustering analysis,complex network analysis,and network topology analysis.Results Among the 202 prescriptions,the overall formula and description by Professor Yang were mild.The four properties and five flavors were dominated by cold,warm and sweet,bitter and spicy.Meridian tropism was mainly lung,stomach,spleen,kidney,heart,liver and large intestine meridians.The frequency analysis also indicated a higher proportion and frequency of deficiency-tonifying herbs,heat-clearing herbs,resolving phlegm,relieving cough and asthma herbs,followed by clearing damp and promoting diuresis herbs,relieving exterior syndrome herbs,expelling wind and dampness herbs,sedative tranquilizing herbs,damp-clearing herbs,qi-regulating herbs,dissipating blood stasis herbs,arresting discharge herbs,resuscitationinducing aromatic herbs,digestant herbs,interior-warming drug and calming liver to stop endogenous wind herbs.The results of association rule mining and Phi coefficient were consistent with the overall principles of medication by Professor Yang,which included supplementing vacuity and supporting right,clearing heat and resolving phlegm and regulating qi-flowing for eliminating dampness.The results of factor analysis and hierarchical clustering analysis revealed the presence of seven common factors and drug combinations.It reflected and emphasized the characteristics of drug application including dispersing lung qi,invigorating spleen and replenishing qi,tranquilizing and sedati

关 键 词：数据挖掘 脓毒症胃肠功能障碍 杨志旭 中药处方 用药经验 

分 类 号：R278[医药卫生—中医学]