黄连降糖方治疗2型糖尿病热盛津伤证临床研究  

Clinical Research on Huanglian Hypoglycemic Formula in the Treatment of Type 2 Diabetes Mellitus with Syndrome of Excessive Heat Damaging Fluid

作　　者：李丽 LI Li(Wan Cheng Qu Hospital of Traditional Chinese Medicine,Nanyang,Henan,China,473000)

机构地区：[1]南阳市宛城区中医院,河南南阳473000

出　　处：《河南中医》2025年第3期435-439,共5页Henan Traditional Chinese Medicine

摘　　要：目的:观察黄连降糖方治疗2型糖尿病热盛津伤证的临床疗效。方法:选取2021年3月至2022年3月在南阳市宛城区中医院就诊的糖尿病热盛津伤证患者80例,随机分为对照组和治疗组,每组各40例,两组均给予基础治疗,对照组给予二甲双胍治疗,治疗组在对照组的基础上采用黄连降糖方治疗,两组均连续治疗8周。评价两组患者的治疗效果及用药安全性,并比较两组治疗前、治疗8周后中医证候积分、糖代谢、血脂、胰岛素、血清指标以及肾功能指标的差异性。结果:对照组有效率为67.50%,治疗组有效率为87.50%,两组有效率比较,差异有统计学意义(P<0.05)。两组患者治疗后中医证候积分较治疗前明显降低,且治疗组低于对照组(P<0.05)。治疗后,两组空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2 hour postprandial plasma glucose,2 hPG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、三酰甘油(triacyl glycerol,TG)、总胆固醇(total cholesterol,TC)、胰岛素抵抗指数(insulin resistance index,HOMA-IR)、视黄醇结合蛋白(retinol-binding protein,RBP4)、脂肪型脂肪酸结合蛋白(fatty acid-binding protein,FABP)、血肌酐(serum creatinine,SCR)、血尿素氮(blood urea nitrogen,BUN)、尿白蛋白排泄率(urinary albumin excretion rates,UAER)显著降低,且治疗组低于对照组(P<0.05);高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、胰岛β细胞功能(β-cell function,HOMA-β)、β抑制蛋白2(β-arrestin 2)显著升高,且治疗组高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:黄连降糖方可改善2型糖尿病热盛津伤证患者的临床症状,调节血糖与血脂,改善胰岛素抵抗,且无明显不良反应。Objective:To observe the clinical efficacy of Huanglian Hypoglycemic Formula on type 2 diabetes mellitus with syndrome of excessive heat damaging fluid.Methods:A total of 80 patients with diabetes mellitus having syndrome of heat excess damaging fluid who were treated at Wan Cheng Qu Hospital of TCM in Nanyang City from March 2021 to March 2022 were selected and randomly divided into the control group and the treatment group,with 40 cases in each group.Both groups were given basic treatment.The control group was then additionally treated with metformin,while the treatment group was further treated with Huanglian Hypoglycemic Formula on the basis of the control group.Both groups were treated continuously for 8 weeks.The therapeutic effects and drug safety of the two groups were evaluated,and the differences in TCM syndrome scores,glucose metabolism,blood lipids,insulin,serum indicators,and renal function indicators before treatment and 8 weeks after treatment were compared between the two groups.Results:The effective rate of the control group was 67.50%,while that of the treatment group was 87.50%.The difference between the two groups was statistically significant(P<0.05).The TCM syndrome scores in both groups were significantly lower after treatment than those before treatment,and the treatment group had lower scores than those of the control group(P<0.05).After treatment,fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2hPG),glycosylated hemoglobin(HbA1c),low density lipoprotein cholesterol(LDL-C),triacyl glycerol(TG),total cholesterol(TC),insulin resistance index(HOMA-IR),retinol-binding protein(RBP4),fatty acid-binding protein(FABP),serum creatinine(Scr),blood urea nitrogen(BUN),and urinary albumin excretion rates(UAER)were significantly reduced in both groups,and the treatment group′s above indicators were lower than those of the control group(P<0.05).High density lipoprotein cholesterol(HDL-C),β-cell function(HOMA-β),andβ-arrestin2 were significantly increased,and the treatment group′s a

关 键 词：2型糖尿病 热盛津伤证 黄连降糖方 

分 类 号：R259.871[医药卫生—中西医结合]