抗SARS-CoV-2天然免疫反应代谢机制的研究进展  

Advances in metabolic mechanism of innate immune response against SARS-CoV-2

作　　者：郝冰冰 陈磊(综述) 刘知晓 韩超峰(审校) HAO Bingbing;CHEN Lei;LIU Zhixiao;HAN Chaofeng(School of Basic Medical Sciences,Naval Military Medical University,Shanghai 200433,China;不详)

机构地区：[1]中国人民解放军海军军医大学基础医学院,上海200433 [2]中国人民解放军海军军医大学组胚教研室,上海200433

出　　处：《中国生物制品学杂志》2025年第2期242-247,共6页Chinese Journal of Biologicals

基　　金：国家自然科学基金面上项目(31970853)。

摘　　要：SARS-CoV-2感染引起的COVID-19给世界各国人民的生命带来巨大威胁,成为全球重大公共卫生挑战。先天免疫系统是人体抵御病毒入侵的第一道防线,在COVID-19发生发展过程中起重要作用。单核巨噬细胞作为先天免疫系统中主要的免疫细胞,其表达的模式识别受体可识别SARS-CoV-2单链RNA和损伤相关分子模式(damage associated molecular patterns,DAMPs),并诱导抗病毒先天免疫反应。但SARS-CoV-2具有较强的免疫逃逸能力,可在宿主细胞内快速扩增及复制,并诱导宿主细胞死亡,从而进一步诱导炎性反应,导致COVID-19进展。研究表明,巨噬细胞浸润诱导的过度炎性反应(即细胞因子风暴)是COVID-19的重要致死机制,且SARS-CoV-2感染过程中,糖酵解的过度活化是病毒免疫逃逸和炎性反应的重要代谢机制,本文对糖代谢在抗SARS-CoV-2先天免疫反应中的研究进展作一综述。COVID-19 caused by SARS-CoV-2 infection poses a great threat to the lives of people around the world and has become a major global public health challenge.The innate immune system is the body's first line of defense against viral invasion and plays an important role in the development of COVID-19.As the main immune cells in the innate immune system,monocyte macrophages have pattern recognition receptors on their surface that recognize SARS-CoV-2 singlestranded RNA and damage associated molecular patterns(DAMPs)and induce antiviral innate immune responses.However,SARS-CoV-2 has a strong immune escape ability and can rapidly expand and replicate in host cells and induce host cell death,which further induces an inflammatory response and exacerbates COVID-19.Studies have shown that macrophage infiltration-induced hyperinflammatory responses(i.e.,cytokine storms)are an important lethal mechanism of COVID-19,and that during SARS-CoV-2 infection,the over-activation of glycolysis is an important metabolic mechanism for viral immune escape and inflammatory response.This paper reviews the related research progress of glucose metabolism in the innate immune response against SARS-CoV-2.

关 键 词：SARS-CoV-2 糖酵解 巨噬细胞 

分 类 号：R392.1[医药卫生—免疫学]