From solid to fluid: The possible role of tissue fluidity in mechanical stretch-induced tissue expansion  

作　　者：Shengzhou Shan Xusong Luo 

机构地区：[1]Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China

出　　处：《Chinese Journal of Plastic and Reconstructive Surgery》2025年第1期56-58,共3页中国整形与重建外科(英文)

基　　金：supported by the National Natural Science Foundation of China(grant nos.82102343 and 82372536);the Shanghai Municipal Health Commission Health Industry Clinical Research Special Program(grant no.20244Y0031);the Shanghai“Rising Stars of Medical Talents”Youth Development Program(Youth Medical Talents-Specialist Program).

摘　　要：Tissue expansion is a widely utilized technique in plastic and reconstructive surgery;however,the biological mechanisms underlying the skin response remain poorly understood.We propose that tissue fluidity,the transition of tissue from a solid-like state to a fluid-like state,plays a pivotal role in enabling the reorganization of the epidermal structure and cellular spatial order,which is essential for effective tissue expansion.Drawing parallels between fluidity in materials science and biological systems,we suggest that the fluid-like behavior in the skin may be critical for mechanical adaptability.Understanding the influence of tissue fluidity may open pathways for modulating this process,potentially enhancing tissue expansion efficiency,reducing procedural duration,and improving clinical outcomes.This perspective highlights the importance of investigating the biological dynamics of tissue fluidity and exploring the potential for targeted manipulation of fluidity-related pathways to optimize tissue expansion.Such advancements could profoundly affect regenerative and reconstructive surgical practices.

关 键 词：Tissue expansion Tissue fluidity Mechanical stretch EPIDERMIS 

分 类 号：R622[医药卫生—整形外科]