从数据到机制:医数交叉驱动肿瘤精准诊疗的研究现状与展望  

From Data to Mechanisms:Medical-Mathematical Integration Driven Advances in Precision Oncology-Current Research Status and Future Perspectives

作　　者：孙端辰 韩仁敏 马成林 段贸腾 王斐[3,4] 刘丙强 Duanchen Sun;Renmin Han;Chenglin Ma;Maoteng Duan;Fei Wang;Bingqiang Liu(School of Mathematics,Shandong University,Jinan 250100,China;Research Center for Mathematics and Interdisciplinary Sciences,Shandong University,Qingdao 266237,China;The Second Hospital,Shandong University,Jinan 250033,China;Shandong Key Laboratory of Cancer Digital Medicine,Jinan 250033,China)

机构地区：[1]山东大学数学学院,济南250100 [2]山东大学数学与交叉科学研究中心,青岛266237 [3]山东大学第二医院,济南250033 [4]山东省癌症数字医疗重点实验室,济南250033

出　　处：《中国科学基金》2025年第1期174-184,共11页Bulletin of National Natural Science Foundation of China

基　　金：国家重点研发计划(2020YFA0712400,2022YFA1004801);国家自然科学基金项目(62272270,62202269)的资助。

摘　　要：测序组学、电子健康记录和医学影像等多维度异质医学数据的迅速积累,不仅凸显了传统还原论研究范式的局限性,同时也为医学研究革新带来机遇。近年来,生物医学与智能信息科学的深度交叉融合取得显著进展,推动了疾病预测与精准医疗的发展进程,数学已逐步成为其底层核心驱动。通过深化医学—数学交叉研究实现对生命系统本质规律的定量解析将成为本领域取得变革性突破的关键路径。本文系统综述了医数交叉领域的研究进展,重点探讨数学模型在肿瘤诊断、治疗及肿瘤发生发展机制解析等方面的关键作用,深入展望医数交叉在机制导向的数学模型构建、数字生命和虚拟健康等领域的创新潜力与应用前景。通过数学模型的精准构建与应用,实现从“数据关联”向“机制解析”的迈进,医数交叉将为肿瘤预防和诊疗提供突破性解决方案,推动医学的高效化、精准化、智能化变革。The rapid accumulation of complex,multi-level,and heterogeneous medical data makes traditional research paradigms less effective.However,it also presents an opportunity to reform current medical research.In recent years,interdisciplinary research in biomedicine and intelligence science has significantly progressed,driving the rapid development of disease prediction and precision medicine,in which mathematics has played a fundamental role.Deep interdisciplinary research in biomedicine and mathematics makes achieving a fundamental characterization of life mechanisms possible.This article reviews the current status of interdisciplinary research in biomedicine and mathematics,exploring the critical role of mathematics in tumor diagnosis,treatment,and the mechanisms underlying tumorigenesis.Next,we discuss interdisciplinary researchs prospects and potential in mathematical model design,digital life,and virtual health.By constructing and applying mathematical models,interdisciplinary research in biomedicine and mathematics is expected to provide powerful cancer prevention and treatment solutions,guiding biomedicine research more efficiently,precisely,and intelligently.

关 键 词：医数交叉 数据分析 数学模型 生物信息学 生物数学 肿瘤诊疗 

分 类 号：R730.5[医药卫生—肿瘤]