虫螨腈对大鼠的慢性毒性与致癌性研究  

Study on chronic toxicity and carcinogenicity of carbofuran in rats

作　　者：胡悦 李国樑[2] 陆丰荣[2] 刘莉莉 HU Yue;LI Guoliang;LU Fengrong;LIU Lili(School of Public Health,Shanxi Medical University,Taiyuan,Shanxi 030001,China;Toxicology Laboratory,Guangdong Province Hospital for Occupational Disease Prevetion and Treatment,Guangzhou,Guangdong 510300,China)

机构地区：[1]山西医科大学公共卫生学院,山西太原030001 [2]广东省职业病防治院毒理实验所,广东广州510300

出　　处：《职业与健康》2025年第1期36-41,共6页Occupation and Health

基　　金：广东省自然科学基金面上项目(2024A1515012530);广东省自然基础与应用基础基金项目(2024A1515013198)。

摘　　要：目的了解虫螨腈对SD大鼠的慢性毒性与致癌作用,分析其作用机制及潜在危害。方法将240只SPF级SD大鼠按体质量随机分为对照(普通饲料)组和低、中、高剂量虫螨腈组,其中,雌性动物染毒剂量分别为0.19、0.76、3.18 mg/(kg·d),雄性动物染毒剂量分别为0.04、0.15、0.64 mg/(kg·d),每组120只,雌雄各半。采用饲喂法对大鼠进行104周的慢性毒性与致癌合并实验。记录大鼠体质量,进行血常规、血生化和组织病理学检查,并计算肿瘤发生率和动物死亡率。结果与对照组相比,中、高剂量组动物死亡率升高,在第3~85周出现体质量均降低,平均血小板体积、血小板平均分布宽度升高,差异均有统计学意义(均P<0.05)。与对照组相比,各虫螨腈剂量组大鼠的肿瘤发生率和多发性肿瘤差异均无统计学意义(均P>0.05)。结论在本研究染毒剂量条件下,未发现虫螨腈对大鼠明显毒作用的靶器官及致癌性。Objective To investigate the chronic toxicity and carcinogenicity of carbofuran in SD rats,analyze its mechanism of action and potential hazards.Methods Totally 240 SPF-grade SD rats were randomly divided into a control(standard diet)group and low,medium and high dose group according to body mass.The female animals were exposed to doses of 0.19,0.76,and 3.18mg/(kg·d),respectively,and the male animals were exposed to doses of 0.04,0.15,and 0.64 mg/(kg·d),respectively.There were120 rats in each group,with half male and half female.A combined chronic toxicity and carcinogenesis experiment was conducted on rats using a feeding method for 104 weeks.The body mass of the rats was weighed,blood routine,blood biochemistry and histopathology were performed,and the tumor incidence and animal mortality rates were calculated.Results Compared with the control group,the mortality rate of animals in the medium and high dose groups increased,and there was a decrease in body mass from week 3 to week 85.The average platelet volume and average platelet distribution width increased,and the differences were statistically significant(all P<0.05).Compared with the control group,there was no statistically significant difference in the incidence of tumors and multiple tumors among the different doses of carbofuran in rats(all P>0.05).Conclusion Under the conditions of the present study's dosing dose,no obvious toxic effects on target organs and carcinogenicity were found.

关 键 词：虫螨腈 慢性毒性 致癌 靶器官 

分 类 号：R114[医药卫生—卫生毒理学]