抗C1q抗体、NF⁃κB与老年类风湿关节炎患者疾病活动度、关节功能的关系  

Relationship between anti⁃C1q antibody,NF⁃κB and disease activity and joint function in elderly patients with rheumatoid arthritis

作　　者：侯宏理 张雪 马琳琳 靳东亮 陈世晓 HOU Hongli;ZHANG Xue;MA Linlin;JIN Dongliang;CHEN Shixiao(Department of Rheumatology,Henan Provincial Orthopaedic Hospital/Luoyang Orthopaedic Hospital,Luoyang,Henan,China,471000)

机构地区：[1]河南省洛阳正骨医院/河南省骨科医院风湿病科,河南洛阳471000

出　　处：《分子诊断与治疗杂志》2025年第1期120-123,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技项目(212102311089)。

摘　　要：目的探讨抗C1q抗体、核转录因子⁃κB(NF⁃κB)与老年类风湿关节炎(RA)患者疾病活动度、关节功能的关系。方法选取2020年4月至2023年5月河南省洛阳正骨医院收治的老年RA患者186例作为研究组,另选取同期于本院体检的老年健康对象186名作为对照组。检测两组血清抗C1q抗体、NF⁃κB水平,采用28个关节的平均疾病活动性(DAS28)评分及健康评估问卷(HAQ)评价关节功能状态,并根据DAS28评分将186例老年RA患者分为缓解组41例(DAS28评分≤2.6分)、低中度活动组85例(2.6分<DAS28评分≤5.1分)、高度活动组60例(DAS28评分>5.1分)。比较各组间血清抗C1q抗体、NF⁃κB水平的差异,采用受试者工作特性(ROC)曲线评估分析血清抗C1q抗体、NF⁃κB水平对老年RA患者疾病活动度的预测价值;采用Pearson相关分析血清抗C1q抗体、NF⁃κB水平与关节功能的关系。结果研究组血清抗C1q抗体、NF⁃κB水平均明显高于对照组,差异有统计学意义(P均<0.05)。老年RA患者血清抗C1q抗体、NF⁃κB水平:高度活动组>低中度活动组>缓解组,差异有统计学意义(P均<0.05)。血清抗C1q抗体、NF⁃κB水平及两者联合预测老年RA患者疾病活动度的AUC分别为0.812(95%CI:0.767~0.862)、0.734(95%CI:0.684~0.779)、0.906(95%CI:0.861~0.956)。老年RA患者DAS28评分、HAQ评分:高度活动组>低中度活动组>缓解组,差异有统计学意义(P均<0.05)。相关分析显示,老年RA患者血清抗C1q抗体、NF⁃κB水平与DAS28评分、HAQ评分均呈正相关(P均<0.001)。结论随着老年RA患者疾病活动度增加,C1q抗体、NF⁃κB水平升高,两指标对老年RA患者疾病活动度及关节功能评估具有一定预测价值,推测二指标可能参与RA的发生发展。Objective To investigate the relationship between anti⁃C1q antibody,nuclear transcription factor⁃κB(NF⁃κB)and disease activity and joint function in elderly patients with rheumatoid arthritis(RA).Methods 186 elderly RA patients admitted to Luoyang Orthopedic Hospital in Henan Province from April 2020 to May 2023 were selected as the study group.Another 186 elderly healthy subjects who underwent physical examinations at our hospital during the same period were chosen as the control group.Serum anti⁃C1q antibody and NF⁃κB levels were measured in both groups,and joint function was assessed using the DAS28 score and Health Assessment Questionnaire(HAQ).Based on the DAS28 score,the 186 elderly RA patients were further categorized into the remission group(41 cases)(DAS28 score≤2.6 points),the mild and moderate active group(85 cases)(2.6 points<DAS28 score≤5.1 points)and highly active group(60 cases)(DAS28 score>5.1 points).The differences in serum anti⁃C1q antibody and NF⁃κB levels among all groups were com⁃pared,and the predictive value of serum anti⁃C1q antibody and NF⁃κB levels on disease activity in elderly RA patients was assessed using ROC analysis.The relationship between serum anti⁃C1q antibody,NF⁃κB levels,and joint function was analyzed through Pearson correlation.Results The serum levels of anti⁃C1q antibodies and NF⁃y,NF⁃κB leveland NF⁃κB levels on disease activity in elderly were seleontrol group,and the differences were statistically significant(P<0.05).The serum levels of anti⁃C1q antibodies and NF⁃B leveland NF⁃κB levels on disease activity in elderly were sel>low to moderate activity group>remission group,with statistically significant differences(P<0.05).The AUC for serum anti⁃C1q antibody,NF⁃cally significant differences(eland NF⁃κB levels on disease activity in elderly were seleontrol groCI:0.767~0.862),0.734(95%CI:0.684~0.779),and 0.906(95%CI:0.861~0.956),respectively.The DAS28 score and HAQ score of elderly RA patients were as follows:high

关 键 词：类风湿关节炎 抗C1Q抗体 核转录因子⁃κB 老年 疾病活动度 

分 类 号：R593.22[医药卫生—内科学]