血清vWF、TAT、MCP⁃1和NF⁃kB水平与不同程度病变冠心病的相关性  

Correlation between serum vWF,TAT,MCP⁃1 and NF⁃κB levels and different degrees of coronary heart disease

作　　者：严红梅 吴锐军 操龙斌 曾令恒 邱欣 YAN Hongmei;WU Ruijun;CAO Longbin;ZENG Lingheng;QIU Xin(Department of Clinical Laboratory,the Seventh Affiliated Hospital of Southern Medical University,Foshan,Gangdong,China,528000)

机构地区：[1]南方医科大学第七附属医院检验科,广东佛山528000

出　　处：《分子诊断与治疗杂志》2025年第1期137-140,共4页Journal of Molecular Diagnostics and Therapy

基　　金：广东省自然科学基金(20220917);佛山市卫生健康局医学科研课题立项申请(20230228)。

摘　　要：目的分析冠心病患者血清血管性血友病因子(vWF)、凝血酶⁃抗凝血酶复合物(TAT)、单核细胞趋化蛋白⁃1(MCP⁃1)和核因子⁃kB(NF⁃kB)水平及与病变程度的相关性。方法选取2022年1月至2024年1月于南方医科大学第七附属医院治疗的冠心病患者154例为观察组,同时选取同期健康志愿者154名为对照组,比较两组以及观察组不同疾病类型、病变程度患者vWF、TAT、MCP⁃1和NF⁃kB水平的差异,采用Spearman相关分析vWF、TAT、MCP⁃1、NF⁃kB与病变程度的关系,采用ROC曲线分析vWF、TAT、MCP⁃1、NF⁃kB诊断中重度病变的效能。结果观察组vWF、TAT、MCP⁃1和NF⁃kB水平明显高于对照组,差异有统计学意义(P<0.05);vWF、TAT、MCP⁃1和NF⁃kB水平:急性心肌梗死>不稳定型心绞痛>稳定型心绞痛,差异有统计学意义(P<0.05);vWF、TAT、MCP⁃1和NF⁃kB水平:重度>中度>轻度,差异有统计学意义(P<0.05)。vWF、TAT、MCP⁃1、NF⁃kB与病变程度呈正相关(P<0.05)。vWF、TAT、MCP⁃1、NF⁃kB及联合诊断中重度病变的ROC曲线下面积分别为0.922、0.908、0.944、0.832和0.700。结论冠心病患者vWF、TAT、MCP⁃1和NF⁃kB水平明显升高,且与疾病类型和病变严重程度相关,在诊断中重度病变中有一定临床应用价值。Objective To explore the levels and clinical significance of von willebrand factor(vWF),thrombin antithrombin complex(TAT),monocyte chemotactic protein⁃1(MCP⁃1),and nuclear factorκB(NF⁃κB)in patients with coronary heart disease.Methods 154 patients with coronary heart disease who were treated at our hospital from January 2022 to January2024 were selected as the observation group,while 154 healthy volunteers were selected as the control group.The differences in vWF,TAT,MCP⁃1,and NF⁃κB levels between the two groups and patients with different types and degrees of disease were compared.Spearman correlation analysis was used to investigate the relationship between vWF,TAT,MCP⁃1,NF⁃κB,and the severity of lesions.The ROC curve analysis was used to evaluate the diagnostic efficacy of vWF,TAT,MCP⁃1,and NF⁃κB for moderate to severe lesions.Results The levels of vWF,TAT,MCP⁃1,and NF⁃κB in the observation group were significantly higher than those in the control group,and the difference was statisti⁃cally significant(P<0.05).The levels of vWF,TAT,MCP⁃1,and NF⁃κB were found to be in the following order:acute myocardial infarction>unstable angina>stable angina,with statistically significant differences(P<0.05).Additionally,the levels of vWF,TAT,MCP⁃1,and NF⁃κB were:severe>moderate>mild,with statis⁃tically significant differences(P<0.05).It was also noted that vWF,TAT,MCP⁃1,and NF⁃κB are positively correlated with the degree of lesions(P<0.05).The areas under the ROC curves for vWF,TAT,MCP⁃1,NF⁃κB,and the combined diagnosis of moderate to severe lesions were 0.922,0.908,0.944,0.832,and 0.700,respectively.Conclusion The levels of vWF,TAT,MCP⁃1,and NF⁃κB significantly increase in patients with coronary heart disease,and this increase is related to the type and severity of the disease.This has a certain application value in diagnosing moderate to severe lesions.

关 键 词：冠心病 血管性血友病因子 凝血酶⁃抗凝血酶复合物 单核细胞趋化蛋白⁃1 核因子⁃kB 

分 类 号：R541.4[医药卫生—心血管疾病]