血清NSE、AQP⁃4、HBP和CRP/PA比值对自发性脑出血术后预后的预测价值  

Prognostic value of serum NSE,AQP⁃4,HBP and CRP/PA in spontaneous intracerebral hemorrhage

作　　者：程子洢[1] 张扬[2] 高宝城 CHENG Ziyi;ZHANG Yang;GAO Baocheng(Operating Room of Lequn Hospital,the First Hospital of Jilin University,Changchun,Jilin,China,130000;Neurosurgery,the First Hospital of Jilin University,Changchun,Jilin,China,130000)

机构地区：[1]吉林大学第一医院乐群院区手术室,吉林长春130000 [2]吉林大学第一医院神经外科,吉林长春130000

出　　处：《分子诊断与治疗杂志》2025年第1期171-174,共4页Journal of Molecular Diagnostics and Therapy

基　　金：吉林大学科技项目(2015Yx052)。

摘　　要：目的分析神经元特异性烯醇化酶(NSE)、人水通道蛋白4(AQP⁃4)、肝素结合蛋白(HBP)及C反应蛋白(CRP)与前白蛋白(PA)比值(CRP/PA)对脑出血(ICH)患者手术预后的预测价值。方法选取2021年11月至2023年12月吉林大学第一医院收治的120例接受手术治疗ICH患者,根据ICH术后神经损伤程度将患者分别纳入轻度损伤组(n=47)、中度损伤组(n=38)、重度损伤组(n=35),根据预后情况将患者分为预后不良组(n=42)和预后良好组(n=78)。比较各组ICH患者术后血清中NSE、AQP⁃4、HBP和CRP/PA比值差异,比较血清中NSE、AQP⁃4、HBP和CRP/PA与患者术后神经功能损伤程度相关性,采用受试者工作特征曲线(ROC)评估各指标单独及联合对ICH患者术后预后的预测价值。结果ICH患者术后血清NSE、AQP⁃4、HBP和CRP/PA比较:轻度损伤组<中度损伤组<。重度损伤组,差异有统计学意义(P<0.05);NSE、AQP⁃4、HBP与CRP/PA与ICH患者术后的神经功能损伤程度均呈正相关(P<0.05);预后不良组患者血清中NSE、AQP⁃4、HBP和CRP/PA比值均高于预后良好组,差异有统计学意义(P<0.05);NSE、AQP⁃4、HBP和CRP/PA比值联合预测ICH患者手术预后AUC 0.910,高于各指标单一预测(P<0.05)。结论CH患者术后血清NSE、AQP⁃4、HBP和CRP/PA比值与神经功能受损程度相关,对患者术后预后具有较高预测价值。Objective To analyze the prognostic value of neuron⁃specific enolase(NSE),human aquaporin 4(AQP⁃4),heparin⁃binding protein(HBP)and C⁃reactive protein(CRP)to prealbumin(PA)ratio(CRP/PA)in patients with intracerebral hemorrhage(ICH).Methods A total of 120 patients with ICH who underwent surgical treatment at the First Hospital of Jilin University were enrolled between November 2021 and December 2023.Based on the severity of nerve injury after ICH surgery,patients were divided into the mild injury group(n=47),the moderate injury group(n=38),and the severe injury group(n=35).Additionally,patients were categorized into the poor prognosis group(n=42)and the good prognosis group(n=78)based on different prognoses.The levels of serum NSE,AQP⁃4,HBP,and CRP/PA were compared among the different groups,and correlations between these above indicators and the severity of nerve injury were examined.The prognostic value of NSE,AQP⁃4,HBP,CRP/PA,and combined detection was assessed using receiver operating characteristic(ROC)curves.Results The levels of serum NSE,AQP⁃4,HBP,and CRP/PA gradually increased in the mild injury group,moderate injury group and severe injury group(P<0.05).These levels were positively correlated with the severity of nerve injury(P<0.05).Additionally,the levels of serum NSE,AQP⁃4,HBP,and CRP/PA in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The AUC of NSE combined with AQP⁃4,HBP,and CRP/PA for predicting prognosis was 0.910,which was greater than that of a single indicator(P<0.05).Conclusion The levels of serum NSE,AQP⁃4,HBP,and CRP/PA are correlated with the severity of nerve injury in ICH patients,all of which have high prognostic value.

关 键 词：脑出血 神经功能受损 神经元特异性烯醇化酶 人水通道蛋白 肝素结合蛋白 C反应蛋白与前白蛋白比值 

分 类 号：R651.12[医药卫生—外科学]