可见光催化合成菲啶类化合物反应研究  

Study on Visible Light Catalyzed Synthesis of Phenanthridine Compounds

作　　者：戴浩 DAI Hao(School of Chemical Engineering,Anhui University of Science and Technology,Huainan 232001,China)

机构地区：[1]安徽理工大学化学工程学院,安徽淮南232001

出　　处：《山东化工》2025年第3期73-76,84,共5页Shandong Chemical Industry

摘　　要：菲啶类化合物构成了一类广泛研究的生物活性化合物,因其在多种生物碱中的普遍存在以及它们在抗菌、抗真菌和抗肿瘤活性方面的显著效果而受到科学界的广泛关注。自20世纪末以来,合成化学家们对这些含有氮杂环的化合物产生了浓厚的兴趣,并开发了多种合成策略来构建具有不同取代基的菲啶骨架,同时努力提高合成效率。然而传统的合成策略在制备菲啶类化合物方面存在一定的局限性,例如步骤复杂和选择性不足,这些因素制约了其在化学合成领域的进一步应用。因此,开发一种高效且具有高选择性的菲啶环C-H键官能化策略,对于推动该领域的科学发展和工业应用具有显著的学术意义和广阔的市场前景。本研究致力于深入探究菲啶环C-H键的官能化反应,旨在通过优化反应条件和筛选高效的催化剂体系,显著提升反应的效率和选择性,以菲啶和对甲基苯磺酰肼为反应物,绿色、高效地合成了一种新的菲啶类化合物。Phenididine compounds constitute a widely studied class of bioactive compounds,which have attracted widespread attention from the scientific community due to their widespread presence in various alkaloids and their significant effects in antibacterial,antifungal,and anti-tumor activities.Since the late 20th century,synthetic chemists have shown a strong interest in compounds containing nitrogen heterocycles and have developed various synthetic strategies to construct phenanthrene frameworks with different substituents,while striving to improve synthesis efficiency.However,traditional synthesis strategies have certain limitations in the preparation of phenanthridine compounds,such as complex steps and insufficient selectivity,which restrict their further application in the field of chemical synthesis.Therefore,developing an efficient and highly selective C-H functionalization strategy for phenanthrene rings has significant academic significance and broad market prospects for promoting scientific development and industrial applications in this field.This study aims to investigate the functionalization reaction of C-H bonds in phenanthrene rings,with the aim of significantly improving the efficiency and selectivity of the reaction by optimizing reaction conditions and screening efficient catalyst systems.A new phenanthrene compound was synthesized in a green and efficient manner using phenanthrene and p-toluenesulfonyl hydrazine as reactants.

关 键 词：菲啶 光催化 二甲基亚砜 

分 类 号：TQ253.2[化学工程—有机化工] O626.32[理学—有机化学]