间苯三酚对舒芬太尼复合丙泊酚在宫腔镜手术患者呼吸循环中的影响效果分析  

Analysis regarding the effectiveness of resorcinol on the effect of sufentanil combined with propofol in the respiratory cycle of patients undergoing hysteroscopic surgery

作　　者：丁旭[1] 曹霞 王鹰 Ding Xu;Cao Xia;Wang Ying(Department of Anesthesiology,Fuxing Hospital affiliated to Capital Medical University,Beijing 100038,China)

机构地区：[1]首都医科大学附属复兴医院麻醉科,北京100038

出　　处：《中华保健医学杂志》2025年第1期141-145,共5页Chinese Journal of Health Care and Medicine

基　　金：北京市西城区卫生健康委员会青年科技人才项目(XWKX2022-21)。

摘　　要：目的探究间苯三酚对舒芬太尼复合丙泊酚在宫腔镜手术应用时对患者呼吸循环的影响。方法收集2023年1月~2023年12月于首都医科大学附属复兴医院接受宫腔镜手术治疗的136例患者的临床资料进行回顾性研究,根据患者术前是否静脉滴注间苯三酚将其分为对照组(n=60)和观察组(n=76)。对照组采用舒芬太尼联合丙泊酚进行麻醉诱导,观察组则在对照组基础上于术前静脉滴注间苯三酚。比较两组患者不同时间呼吸循环功能[平均动脉压(MAP)、心率(HR)和呼吸频率(RR)]指标;比较两组患者麻醉效果;比较两组患者术后1 h Ramsay评分和视觉模拟评分法(VAS)评分情况;比较两组患者手术前后免疫功能及术后不良反应发生情况。结果给药前和术毕时,两组患者呼吸循环功能指标比较,差异均无统计学意义(P>0.05);手术5 min时,观察组患者的MAP、RR水平均高于对照组患者,HR低于对照组患者[(85.98±10.12)mmHg vs.(72.89±6.02)mmHg、(15.63±1.56)次∕min vs.(12.04±2.75)次∕min,(75.26±8.54)次∕min vs.(82.65±5.13)次∕min],差异均有统计学意义(t=8.856、8.856、5.911,P<0.05)。观察组患者的麻醉起效时间和术后意识恢复时间均短于对照组患者,术后1 h VAS评分低于对照组患者,而术后1 h Ramsay评分高于对照组患者[(2.08±0.29)min vs.(2.48±0.45)min、(6.16±2.08)min vs.(9.28±1.52)min、(2.48±0.72)分vs.(2.76±0.82)分、(3.12±0.92)分vs.(2.71±0.89)分],差异均有统计学意义(t=6.275、9.742、2.118、2.618,P<0.05)。术前1 d,两组患者的T淋巴细胞亚群水平比较,差异均无统计学意义(P>0.05);术后1 d,观察组患者血清中CD3^(+)、CD4^(+)水平及CD4^(+)∕CD8^(+)均高于对照组患者,而CD8^(+)水平低于对照组患者[(54.35±4.15)vs.(49.65±5.02)、(35.34±3.12)vs.(31.59±2.26)、(28.59±3.24)vs.(28.96±3.29)、(1.38±0.17)vs.(1.21±0.13)],差异均有统计学意义(5.977、7.827、6.406、0.657,P<0.05)。观察组患者术后不良反�Objective To investigate the effect of resorcinol on the effects of a combination of sufentanil and propofol on the patient's respiratory circulation during operative application of uteroscopy.Methods The clinical data of 136 patients who underwent hysteroscopic surgery at the Affiliated Fuxing Hospital of Capital Medical University from January 2023 to December 2023 were retrospectively analyzed.The patients were divided into the control group(n=60)and the observation group(n=76)based on whether they received intravenous infusion of phloroglucinol before the operation.In the control group,sufentanil and propofol were used to induce anaesthesia,and in the observation group,resorcinol was injected intravenously before the operation on the basis of the control group.The observation group used sufentanil combined with propofol to induce anaesthesia,while the observation group used intravenous resorcinol before the operation.The general data of the patients in the two groups were counted,and the differences in respiratory and circulatory function,anaesthesia effect,Ramsay and VAS scores,and immune function were compared between the two groups.Results Both groups showed no significant differences in MAP,HR,and RR levels before drug administration and at the end of surgery(P>0.05).However,during surgery at the 5-minute mark,the observation group had significantly higher MAP(85.98±10.12)mmHg and RR(15.63±1.56)breaths∕min compared to the control group,while the HR(75.26±8.54)beats∕min was significantly lower than that of the control group,with statistically significant differences(t=8.856,5.911,9.597,P<0.05).The observation group had a shorter onset time(2.08±0.29)min and postoperative consciousness recovery time(6.16±2.08)min compared to the control group,along with a lower postoperative 1-hour VAS score(2.48±0.72)and a higher Ramsay score(3.12±0.92),with statistically significant differences(t=6.275,9.742,2.618,2.118,P<0.05).There were no significant differences in T-lymphocyte subpopulation levels between t

关 键 词：间苯三酚 舒芬太尼 丙泊酚 宫腔镜 呼吸循环 

分 类 号：R614[医药卫生—麻醉学]