慢性心力衰竭患者血清氧化应激标志物超氧化物歧化酶、丙二醛、一氧化氮、一氧化氮合酶与心室重塑的相关性  

Correlation between serum markers of oxidative stress such as superoxide dismutase,malondialdehyde,nitric oxide,nitric oxide synthase and ventricular remodeling in patients with chronic heart failure

作　　者：赖心味 赖慧 郭松 LAI Xinwei;LAI Hui;GUO Song(Department of Cardiology,Shangyou County People's Hospital,Jiangxi Province,Shangyou341200,China)

机构地区：[1]江西省上犹县人民医院心内科,江西上犹341200

出　　处：《中国当代医药》2025年第6期16-19,26,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202310836)。

摘　　要：目的探究血清氧化应激因子超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、一氧化氮合酶(NOS)水平与慢性心力衰竭患者心室重塑的关系。方法选取2021年2月至2023年2月上犹县人民医院112例慢性心力衰竭患者作为研究对象,依照是否发生心室重塑分为心室重塑组和非心室重塑组,比较两组患者SOD、MDA、NO、NOS水平差异,探究各指标与其心室重塑的关系。结果心室重塑组MDA、NO、NOS、左心室质量指数(LVMI)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)水平高于非心室重塑组,SOD、左室射血分数(LVEF)水平低于非心室重塑组,差异有统计学意义(P<0.05)。Pearson相关性分析可知,SOD水平与LVMI、LVESV、LVEDV水平呈负相关(r=-0.586,-0.676,-0.711,P<0.05),与LVEF水平呈正相关(r=0.289,P<0.05)。MDA水平与LVMI、LVESV、LVEDV水平呈正相关(r=0.621,0.657,0.723,P<0.05),与LVEF水平呈负相关(r=-0.302,P<0.05)。NO水平与LVMI、LVESV、LVEDV水平呈正相关(r=0.614,0.702,0.777,P<0.05),与LVEF水平呈负相关(r=-0.220,P<0.05)。NOS水平与LVMI、LVESV、LVEDV水平呈正相关(r=0.646,0.679,0769,P<0.05),与LVEF水平呈负相关(r=-0.312,P<0.05)。SOD、MDA、NO、NOS、LVMI、LVESV、LVEDV、LVEF对患者心脏重塑的预测AUC为0.873、0.896、0.888、0.887、0.844、0.881、0.877、0.679,将上述指标中AUC高于0.750的指标进行联合预测,其预测AUC为0.918。结论SOD、MDA、NO、NOS等氧化应激因子水平与慢性心力衰竭患者的心室重塑有密切关系,能够反映心脏结构和功能的变化,可作为评估心室重塑进程的生物标志物。Objective To investigate the relationship between the levels of serum oxidative stress factors superoxide dismutase(SOD),malondialdehyde(MDA),nitric oxide(NO),nitric oxide synthase(NOS)and ventricular remodeling in patients with chronic heart failure.Methods A total of 112 patients with chronic heart failure from Shangyou County People's Hospital from February 2021 to February 2023 were selected as the study objects,and they were divided into ventricular remodeling group and non-ventricular remodeling group according to whether ventricular remodeling occurred.The levels of SOD,MDA,NO and NOS between the two groups were compared to explore the relationship between each index and ventricular remodeling.Results The levels of MDA,NO,NOS,left ventricular mass index(LVMI),left ventricular end-systolic volume(LVESV)and left ventricular end-diastolic volume(LVEDV)in the ventricular remodeling group were higher than those in the non-ventricular remodeling group,and the levels of SOD and left ventricular ejection fraction(LVEF)were lower than those in the non-ventricular remodeling group,with statistical significances(P<0.05).According to Pearson correlation analysis,SOD level was negatively correlated with LVMI,LVESV and LVEDV levels(r=-0.586,-0.676,-0.711,P<0.05),and positively correlated with LVEF level(r=0.289,P<0.05).MDA levels were positively correlated with LVMI,LVESV and LVEDV levels(r=0.621,0.657,0.723,P<0.05),and negatively correlated with LVEF level(r=-0.302,P<0.05).NO levels were positively correlated with LVMI,LVESV and LVEDV levels(r=0.614,0.702,0.777,P<0.05),and negatively correlated with LVEF level(r=-0.220,P<0.05).NOS levels were positively correlated with LVMI,LVESV and LVEDV levels(r=0.646,0.679,0769,P<0.05),and negatively correlated with LVEF level(r=-0.312,P<0.05).The predicted AUC values of SOD,MDA,NO,NOS,LVMI,LVESV,LVEDV and LVEF for patients with cardiac remodeling were 0.873,0.896,0.888,0.887,0.844,0.881,0.877 and 0.679.The index with AUC higher than 0.750 in the above indicators is jointly predict

关 键 词：氧化应激 超氧化物歧化酶 丙二醛 一氧化氮 一氧化氮合酶 心室重塑 慢性心力衰竭 

分 类 号：R543.1[医药卫生—心血管疾病]