桂枝茯苓胶囊对EB病毒感染引起的凝血系统异常的影响研究  

Effect research of Guizhi Fuling Capsules on abnormal coagulation system caused by EB virus infection

作　　者：高圣 袁腾飞 唐金凤[1] 杨小燕[1] 李长昊 刘卫兰[1] GAO Sheng;YUAN Tengfei;TANG Jinfeng;YANG Xiaoyan;LI Changhao;LIU Weilan(Department of Laboratory,Ganzhou People's Hospital,Jiangxi Province,Ganzhou341000,China)

机构地区：[1]江西省赣州市人民医院检验科,江西赣州341000

出　　处：《中国当代医药》2025年第6期36-39,44,共5页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023B0651)。

摘　　要：目的探讨桂枝茯苓胶囊在EB病毒感染患者中的临床疗效。方法选取2023年1月至12月赣州市人民医院收治的60例EB病毒感染患者作为研究对象,按照随机数字表法将其分为对照组与观察组,每组30例。对照组采用常规抗病毒治疗,观察组采用常规抗病毒联合桂枝茯苓胶囊治疗,比较两组患者凝血指标水平、血小板、不良反应发生率、总有效率。结果治疗后,两组患者血清血管性假血友病因子(vWF)、纤维蛋白降解产物(FDP)、D-二聚体(D-D)、血浆纤维蛋白原(FBG)低于本组治疗前,且凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)高于本组治疗前,观察组vWF、FDP、D-D、FBG低于对照组,PT、APTT高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者血小板计数(PLT)高于本组治疗前,血小板体积分布宽度(PDW)、血小板平均容积(MPV)低于本组治疗前,观察组PLT、PDW水平高于对照组,MPV低于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论桂枝茯苓胶囊治疗EB病毒感染患者可恢复其凝血功能,能够达到预期疗效,值得临床推广。Objective To investigate the clinical effect of Guizhi Fuling Capsules in patients with Epstein-Barr virus infection.Methods A total of 60 patients with Epstein-Barr virus infection admitted to Ganzhou People's Hospital from January to December 2023 were selected as research objects,and they were divided into control group and observation group according to random number table method,with 30 cases in each group.The control group was treated with conventional antiviral therapy,and the observation group was treated with conventional antiviral combined with Guizhi Fuling Capsules.The coagulation index level,platelet,incidence of adverse reactions and total effective rate of the two groups were compared.Results After treatment,serum von Willebrand factor(vWF),fibrin degradation product(FDP),D-dimer(D-D)and plasma fibrinogen(FBG)in two groups were lower than those before treatment,and prothrombin time(PT)and activated partial thromboplastin time(APTT)were higher than those before treatment,the vWF,FDP,D-D and FBG of the observation group were lower than those of the control group,while the PT and APTT of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,platelet count(PLT)in two groups were higher than those before treatment,and platelet volume distribution width(PDW)and mean platelet volume(MPV)in two groups were lower than those before treatment,PLT and PDW indexes in observation group were higher than those of control group,MPV was lower than that of control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Guizhi Fuling Capsules can restore the coagulation function of patients infected with Epstein-Barr virus,and can achieve the expected effect,which is worthy of clinical promotion.

关 键 词：EB病毒 桂枝茯苓胶囊 凝血功能 临床疗效 血小板 

分 类 号：R725.1[医药卫生—儿科]