四味姜黄汤散对维持性血液透析患者微炎症及颈动脉内膜中层厚度的影响  

Effect of Siwei Jianghuangtang San on micro inflammation and carotid intima-media thickness in maintenance hemodialysis patients

作　　者：周娲 李青春[1] 文君[1] 周兰 钟爱民[1] ZHOU Wa;LI Qingchun;WEN Jun;ZHOU Lan;ZHONG Aimin(Department of Nephrology,Jiangxi Provincial People's Hospital,the First Affiliated Hospital of Nanchang Medical College,Jiangxi Province,Nanchang330006,China;Department of Ultrasound,Jiangxi Provincial People's Hospital,the First Affiliated Hospital of Nanchang Medical College,Jiangxi Province,Nanchang330006,China)

机构地区：[1]江西省人民医院南昌医学院第一附属医院肾内科,江西南昌330006 [2]江西省人民医院南昌医学院第一附属医院超声诊断科,江西南昌330006

出　　处：《中国当代医药》2025年第6期45-49,共5页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2021A087)。

摘　　要：目的探讨四味姜黄汤散对维持性血液透析(MHD)患者微炎症及颈动脉内膜中层厚度(CIMT)的影响。方法选取2021年1月至2022年12月在江西省人民医院肾内科79例MHD患者和体检科体检的20例健康者作为研究对象,根据透析时间将MHD患者分为MHD治疗组(41例)及MHD对照组(38例)。采用彩色多普勒超声测定各组CIMT。四味姜黄汤散治疗前后检测各组血清超敏C反应蛋白(hs-CRP)、正五聚素蛋白3(PTX3)水平,单核细胞/淋巴细胞比值(MLR),分析微炎症状态与CIMT关系。结果MHD组hs-CRP、MLR、PTX3的水平及CIMT高于健康对照组,差异有统计学意义(P<0.05);MHD治疗组治疗后hs-CRP、MLR、PTX3的水平低于本组治疗前,差异有统计学意义(P<0.05);MHD治疗组治疗前后CIMT比较,差异无统计学意义(P>0.05)。按照CIMT值分组后发现,治疗前MHD治疗组中度组PTX3水平高于轻度组,差异有统计学意义(P<0.05);MHD治疗组中度组和轻度组的hs-CRP、MLR水平比较,差异无统计学意义(P>0.05);MHD治疗组重度组hs-CRP、MLR、PTX3水平高于轻度组、中度组,差异有统计学意义(P<0.05)。结论MHD患者存在微炎症状态,微炎症状态与CIMT密切相关。四味姜黄汤散能通过改善MHD患者的微炎症状态,对MHD患者的心血管事件发生发展起到防治作用。Objective To investigate the effects of Siwei Jianghuangtang San on microinflammation and carotid intima-media thickness(CIMT)in patients with maintenance hemodialysis(MHD).Methods A total of 79 patients with MHD in the Department of Nephrology of Jiangxi Provincial People's Hospital from January 2021 to December 2022 and 20 healthy patients who were examined in the Department of Physical Examination were selected as the research objects.According to the dialysis time,the patients with MHD were divided into the MHD treatment group(41 cases)and the MHD control group(38 cases).Color Doppler ultrasound was used to measure CIMT in each group.Serum levels of hypersensitive C-reactive protein(hs-CRP),pentraxin 3(PTX3)and monocyte/lymphocyte ratio(MLR)were detected before and after treatment of Siwei Jianghuangtang San,and the relationship between microinflammation and CIMT was analyzed.Results The levels of hs-CRP,MLR,PTX3 and CIMT in MHD group were higher than those in healthy control group,and the differences were statistically significant(P<0.05).The levels of hs-CRP,MLR and PTX3 in MHD treatment group after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).There was no significant difference in CIMT before and after treatment in MHD treatment group(P>0.05).According to the CIMT value,the level of PTX3 in the moderate MHD treatment group was higher than that in the mild MHD treatment group before treatment,and the difference was statistically significant(P<0.05).There were no significant differences in hs-CRP and MLR levels between moderate and mild MHD treatment groups(P>0.05).The levels of hs-CRP,MLR and PTX3 in severe MHD treatment group were higher than those in mild group and moderate group,and the differences were statistically significant(P<0.05).Conclusion MHD patients have microinflammatory state,which is closely related to CIMT.Siwei Jianghuangtang San can prevent and cure the occurrence and development of cardiovascular events in MHD patients by im

关 键 词：四味姜黄汤散 超敏C反应蛋白 单核细胞/淋巴细胞比值 正五聚素蛋白3 颈动脉内膜中层厚度 

分 类 号：R277.5[医药卫生—中医学]