小儿清炎合剂联合阿比多尔治疗热毒袭肺证儿童流行性感冒的效果及安全性  

Efficacy and safety of Xiaoer Qingyan Mixture combined with Arbidol in the treatment of influenza in children with heat toxicity attacking lung syndrome

作　　者：刘洪[1] 徐艳梅[1] 熊丽娟 徐灵均 陈月[1] LIU Hong;XU Yanmei;XIONG Lijuan;XU Lingjun;CHEN Yue(Department of Emergency Medicine,Jiangxi Provincial Children's Hospital,the Affiliated Children's Hospital of Nanchang Medical College,Jiangxi Province,Nanchang330038,China)

机构地区：[1]江西省儿童医院南昌医学院附属儿童医院急诊医学科,江西南昌330038

出　　处：《中国当代医药》2025年第6期91-95,101,共6页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2020A0260)。

摘　　要：目的探讨小儿清炎合剂联合凝血酶抑制剂阿比多尔治疗儿童流行性感冒的效果及安全性。方法选取2022年6月至7月江西省儿童医院收治的150例热毒袭肺证流行性感冒患儿作为研究对象,采用巢氏病例对照研究设计,按照1∶2原则分为观察组(30例)和对照组(共120例,对照A组60例,对照B组60例)。观察组采用小儿清炎合剂联合盐酸阿比多尔颗粒治疗,对照A组采用奥司他韦联合小儿肺热咳喘口服液治疗,对照B组采用奥司他韦联合小儿清炎合剂治疗。比较三组患儿流感症状总积分改善率、症状缓解时间、药物不良反应、临床效果、临床转归情况。结果三组患儿发热、乏力、咳嗽等流感症状缓解时间比较,差异无统计学意义(P>0.05)。观察组呕吐缓解时间短于对照A组,差异有统计学意义(P<0.05)。观察组呕吐缓解时间与对照B组比较,差异无统计学意义(P>0.05)。三组患儿治疗总有效率比较,差异无统计学意义(P>0.05)。三组患儿流感症状积分比较,差异无统计学意义(P>0.05)。三组患儿的不良反应发生率比较,差异无统计学意义(P>0.05)。三组患儿临床合并惊厥、使用抗菌药及住院率比较,差异无统计学意义(P>0.05)。结论小儿清炎合剂联合阿比多尔治疗热毒袭肺证儿童流行性感冒安全有效,改善夏季流感呕吐症状效果,不增加不良反应。Objective To investigate the efficacy and safety of Xiaoer Qingyan Mixture combined with thrombin inhibitor Arbidol in the treatment of influenza in children.Methods A total of 150 influenza children with heat toxicity attacking lung syndrome treated in Jiangxi Provincial Children's Hospital from June to July 2022 were selected as the study objects.A case-control study design was adopted and they were divided into observation group(30 cases)and control group(120 cases,60 cases in control group A and 60 cases in control group B)according to the principle of 1∶2.Observation group was treated with Xiaoer Qingyan Mixture combined with Arbidol Hydrochloride Granules,control group A was treated with Oseltamivir combined with Xiaoer Ferekechuan Oral Liquid,control group B was treated with Oseltamivir combined with Xiaoer Qingyan Mixture.The improvement rate of total score of influenza symptoms,symptom remission time,adverse drug reaction,clinical effect and clinical outcome of the three groups were compared.Results There were no significant differences in the remission time of influenza symptoms such as fever,fatigue and cough among the three groups(P>0.05).The remission time of vomiting in observation group was shorter than that in control group A,and the difference was statistically significant(P<0.05).There was no significant difference in vomiting remission time between observation group and control group B(P>0.05).There was no significant difference in the total effective rate among the three groups(P>0.05).There was no significant difference in the scores of influenza symptoms among the three groups(P>0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).There were no significant differences in the clinical combination of convulsion,use of antibiotics and hospitalization rate among the three groups(P>0.05).Conclusion The combination of Xiaoer Qingyan Mixture and Arbidol is safe and effective in the treatment of children's influenza with heat toxin attackin

关 键 词：小儿清炎合剂 阿比多尔 流行性感冒 儿童 

分 类 号：R725.6[医药卫生—儿科]