血清糖类抗原125、人附睾蛋白4、中性粒细胞与淋巴细胞比值与子宫内膜癌患者新辅助化疗治疗效果的关系  

Relationship between serum carbohydrate antigen 125,human epididymis protein 4,neutrophil-to-lymphocyte ratio and efficacy of neoadjuvant chemotherapy in patients with endometrial cancer

作　　者：刘琴 许爱华 黄婷 LIU Qin;XU Aihua;HUANG Ting(Department of Obstetrics and Gynecology,Ganzhou Women and Children’s Health Care Hospital,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣州市妇幼保健院妇产科,江西赣州341000

出　　处：《癌症进展》2025年第2期185-188,共4页Oncology Progress

基　　金：江西省中医药管理局科技计划项目(2022B403);赣州市指导性科技计划项目(GZ2020ZSF318)。

摘　　要：目的分析血清糖类抗原125(CA125)、人附睾蛋白4(HE4)、中性粒细胞与淋巴细胞比值(NLR)与子宫内膜癌(EC)患者新辅助化疗(NAC)治疗效果的关系。方法选取93例行NAC治疗的EC患者,所有患者均完成3个周期NAC治疗并进行随访,根据疗效评价结果将完全缓解、部分缓解患者纳入缓解组,疾病稳定和疾病进展患者纳入无效组,比较两组患者的临床特征。使用全自动血液分析仪检测中性粒细胞计数与淋巴细胞计数,并计算NLR,采用酶联免疫吸附试验测定血清CA125、HE4水平,比较两组患者的CA125、NLR、HE4水平。采用Logistic回归模型分析EC患者NAC疗效的影响因素。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析CA125、HE4、NLR单独及联合检测对EC患者NAC疗效的预测价值。结果93例EC患者中,完全缓解23例,部分缓解36例,疾病稳定20例,疾病进展14例。无效组(n=34)和缓解组(n=59)患者的年龄、体重指数、分娩次数、临床分期、分化程度、病理类型比较,差异均无统计学意义(P﹥0.05)。无效组患者CA125、HE4、NLR水平均明显高于缓解组,差异均有统计学意义(P﹤0.01)。Logistic回归分析结果显示,CA125、HE4、NLR水平高均是EC患者NAC治疗无效的危险因素(P﹤0.01)。ROC曲线显示,CA125、HE4、NLR单独及联合检测预测EC患者NAC疗效的AUC均﹥0.71,有一定预测价值,且联合检测预测价值最高。结论CA125、HE4、NLR水平与EC患者NAC治疗效果有关,各指标过表达可能会增加NAC治疗无效的风险,这些指标对NAC治疗效果有一定的预测价值,且联合检测预测价值最高。Objective To analyze the relationship between serum carbohydrate antigen 125(CA125),human epididymitis protein 4(HE4),neutrophil-to-lymphocyte ratio(NLR)and efficacy of neoadjuvant chemotherapy(NAC)in patients with endometrial cancer(EC).Method A total of 93 EC patients who underwent NAC treatment were selected.All patients completed 3 cycles of NAC treatment and were followed up.According to the efficacy evaluation results,patients with complete remission and partial remission were included in the remission group,patients with stable disease and progressive disease were included in the ineffective group,and the clinical features of the two groups were compared.The neutrophil count and lymphocyte count were detected by automatic blood analyzer,and NLR was calculated.The levels of serum CA125 and HE4 were detected by enzyme-linked immunosorbent assay,and the levels of CA125,NLR,and HE4 in the two groups were compared.The Logistic regression model was used to analyze the influencing factors of the efficacy of NAC in EC patients.The receiver operating characteristic(ROC)curve and area under the curve(AUC)were used to analyze the predictive value of CA125,HE4,NLR single and combined detection for the efficacy of NAC in EC patients.Result Among 93 EC patients,23 had complete remission,36 had partial remission,20 had stable disease,and 14 had progressive disease.There were no statistically significant differences in age,body mass index,number of deliveries,clinical stage,degree of differentiation,and pathological type between the ineffective group(n=34)and the remission group(n=59)(P>0.05).The levels of CA125,HE4,and NLR in the ineffective group were significantly higher than those in the remission group,and the differences were statistically significant(P<0.01).The results of Logistic regression analysis showed that high levels of CA125,HE4,and NLR were risk factors for ineffective NAC treatment in EC patients(P<0.01).The ROC curve showed that the AUC of CA125,HE4,NLR single and combined detection for predicting the e

关 键 词：子宫内膜癌 新辅助化疗 糖类抗原125 人附睾蛋白4 中性粒细胞与淋巴细胞比值 

分 类 号：R737.33[医药卫生—肿瘤]