知柏地黄汤治疗老年T2DM的效果及免疫功能、炎症因子水平的影响  

The effect of Zhibai Dihuang Tang on the treatment of elderly T2DM and the influence of immune function and inflammatory factor levels

作　　者：张敏 白永胜 高全彩 ZHANG Min;BAI Yongsheng;GAO Quancai(Department of Geriatry,Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Shaanxi,Xianyang 712000,China;Department of Geriatrics,Baoji Central Hospital,Baoji,Shaanxi 721000,China)

机构地区：[1]陕西中医药大学附属医院老年病科,陕西咸阳712000 [2]宝鸡市中心医院老年医学科,陕西宝鸡721000

出　　处：《四川中医》2025年第2期129-133,共5页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨知柏地黄汤治疗T2DM的效果及对免疫功能、炎症因子水平的影响。方法:将我院2020年6月~2022年6月收治的84例老年2型糖尿病患者纳入研究,按照随机数字表法分为观察组与对照组,每组各42例。对照组给予阿卡波糖治疗,观察组给予阿卡波糖^(+)知柏地黄汤治疗,疗程均持续8w。比较两组临床疗效,比较两组治疗前后中医症状积分,检测比较两组治疗前后血糖指标[空腹血糖(FBG)、餐后2h血糖(2hPBG)、糖化血红蛋白(HbA1c)]水平,检测比较两组治疗前后免疫功能[CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)]水平,检测比较两组治疗前后炎症[超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-6、IL-8]水平,记录两组不良反应。结果:观察组疗效优于对照组(P<0.05)。治疗后,观察组与对照组各项中医症状积分均较治疗前要低(P<0.05),且观察组各项中医症状积分较对照组要低(P<0.05)。治疗后,观察组与对照组FBG、2hPBG、HbA1c水平均较治疗前要低(P<0.05),且观察组FBG、2hPBG、HbA1c水平较对照组要低(P<0.05)。治疗后,观察组与对照组CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前要高(P<0.05),观察组与对照组CD8^(+)水平均较治疗前要低(P<0.05),且观察组CD4^(+)、CD4^(+)/CD8^(+)水平较对照组要高(P<0.05),观察组CD8^(+)水平较对照组要低(P<0.05)。治疗后,观察组与对照组hs-CRP、IL-6、IL-8水平均较治疗前要低(P<0.05),且观察组hs-CRP、IL-6、IL-8水平较对照组要低(P<0.05)。两组不良反应无差异(P>0.05)。结论:知柏地黄汤联合阿卡波糖对于老年2型糖尿病患者的疗效优于单一使用阿卡波糖,能够减轻患者症状,改善血糖代谢及免疫功能,减轻炎症,同时安全性较高,具有临床应用价值。Objective:To explore the effect of Zhibai Dihuang Decoction on elderly type 2diabetes and its influence on immune function and inflammatory factor level.Methods:84elderly patients with type 2diabetes admitted to our hospital from June 2020to June 2022were included in the study,and were divided into an observation group and a control group according to the random number table,with 42cases in each group.The control group was treated with acarbose,while the observation group was treated with acarbose^(+)Zhibai Dihuang Tang,with a duration of 8weeks.Compare the clinical efficacy of two groups,compare the traditional Chinese medicine symptom scores before and after treatment,detect and compare the levels of blood glucose indicators[fasting blood glucose(FBG),2-hour postprandial blood glucose(2h PBG),and glycated hemoglobin(HbA1c)]before and after treatment in both groups,and detect and compare the levels of immune function[CD4^(+),CD8^(+),CD4^(+)/CD8^(+)]before and after treatment in both groups,detect and compare the levels of inflammation[high-sensitivity C-reactive protein(hs CRP),interleukin-6,IL-8]before and after treatment between two groups,and record the adverse reactions of the two groups.The therapeutic effect of the observation group was better than that of the control group(P<0.05).After treatment,the TCM symptom scores of both the observation group and the control group were lower than before treatment(P<0.05),and the TCM symptom scores of the observation group were lower than those of the control group(P<0.05).After treatment,the levels of FBG,2h PBG,and HbA1c in the observation group and control group were lower than before treatment(P<0.05),and the levels of FBG,2h PBG,and HbA1c in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CD4^(+),CD4^(+)/CD8^(+)in the observation group and control group were higher than before treatment(P<0.05),while the levels of CD8^(+)in the observation group and control group were lower than before treatment(P<0.05).In a

关 键 词：2型糖尿病 老年 阿卡波糖 知柏地黄汤 免疫 

分 类 号：R259[医药卫生—中西医结合]