平胃温胆汤联合多潘立酮治疗对功能性消化不良患儿临床疗效、胃排空功能及胃肠激素水平的影响  

Effects of Pingwei Wendan Decoction combined with domperidone on clinical curative effect,gastric emptying function and gastrointestinal hormones in children with functional dyspepsia

作　　者：张静[1] 王瑶[2] 崔健 ZHANG Jing;WANG Yao;CUI Jian(Pharmacy Department,2.Medical Department,Beijing Daxing District People's Hospital,Beijing 102600,China)

机构地区：[1]北京市大兴区人民医院药剂科,北京102600 [2]北京市大兴区人民医院中医科,北京102600

出　　处：《四川中医》2025年第2期156-159,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探究平胃温胆汤联合多潘立酮治疗对功能性消化不良(FD)患儿临床疗效、胃排空功能及胃肠激素水平的影响。方法:回顾性选择本院2022年8月~2023年8月收治的FD患儿120例为研究对象,据治疗手段分成西药组(55例)和联合组(65例)。西药组予以多潘立酮治疗,联合组在此基础上联合组予以平胃温胆汤治疗,时长为4周。比较两组疗效、中医证候积分、胃排空功能、胃肠激素、用药安全性和复发率的差异。结果:治疗后,联合组的总有效率高于西药组(P<0.05);两组中医证候积分均低于同组治疗前,且联合组低于西药组(P<0.05);两组胃半排空时间、生长抑素(SS)、舒血管肠肽(VIP)水平均低于同组治疗前,胃窦收缩频率、收缩幅度、运动指数、胃泌素(GAS)、胃动素(MTL)水平均高于同组治疗前,且联合组改善程度优于西药组(P<0.05);两组不良反应发生率无明显差异(P>0.05);随访3个月联合组复发率低于西药组(6.15%vs 18.18%,P<0.05)。结论:平胃温胆汤联合多潘立酮治疗FD患儿的疗效显著,能有效改善中医证候,增强胃排空功能,改善胃肠激素水平,减少疾病复发,且安全性高。Objective:To explore the effects of Pingwei Wendan Decoction combined with domperidone on clinical curative effect,gastric emptying function and gastrointestinal hormones in children with functional dyspepsia(FD).Methods:A retrospective analysis was performed on the clinical data of 120children with FD admitted to the hospital between August 2022and August 2023.According to different treatment methods,they were divided into western medicine group(55cases,domperidone)and combination group(65cases,Pingwei Wendan Decoction+domperidone).All were treated for 4weeks.The differences in curative effect,scores of TCM syndromes,gastric emptying function,gastrointestinal hormones,medication safety and recurrence rate between the two groups were compared.Results:After treatment,total response rate of combination group was higher than that of western medicine group(P<0.05).After treatment,scores of TCM syndromes were decreased in both groups,which were lower in combination group than western medicine group(P<0.05).After treatment,ontraction frequency of gastric antrum,amplitude,motion index,levels of gastrin(GAS)and motilin(MTL)were increased,while gastric half-emptying time,levels of somatostatin(SS)and vasoactive intestinal peptide(VIP)were decreased in both groups,and the improvement was better in combination group than western medicine group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).After 3months of follow-up,recurrence rate of combination group was lower than that of western medicine group(6.15%vs 18.18%,P<0.05).Conclusion:The curative effect of Pingwei Wendan Decoction combined with domperidone is significant in FD children,which can effectively improve TCM syndromes,enhance gastric emptying function,improve gastrointestinal hormones and reduce disease recurrence,with high safety.

关 键 词：功能性消化不良 儿童 多潘立酮 平胃温胆汤 胃排空功能 胃肠激素 

分 类 号：R256.3[医药卫生—中医内科学]